Mechanism of cardioprotection: What can we learn from females?

Elizabeth Murphy, Claudia Lagranha, Anne Deschamps, Mark Kohr, Tiffany Nguyen, Renee Wong, Junhui Sun, Charles Steenbergen

Research output: Contribution to journalArticlepeer-review


This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.

Original languageEnglish (US)
Pages (from-to)354-359
Number of pages6
JournalPediatric Cardiology
Issue number3
StatePublished - Mar 2011


  • Cardioprotection
  • Estrogen signaling
  • G-protein-coupled receptor
  • Nuclear estrogen receptors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine


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