Mechanism of cardioprotection

What can we learn from females?

Elizabeth Murphy, Claudia Lagranha, Anne Deschamps, Mark Kohr, Tiffany Nguyen, Renee Wong, Junhui Sun, Charles Jr Steenbergen

Research output: Contribution to journalArticle

Abstract

This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.

Original languageEnglish (US)
Pages (from-to)354-359
Number of pages6
JournalPediatric Cardiology
Volume32
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Estrogens
Estrogen Receptor beta
Estrogen Receptor alpha
G-Protein-Coupled Receptors
Phosphatidylinositol 3-Kinases
Cardiac Myocytes
Nitric Oxide

Keywords

  • Cardioprotection
  • Estrogen signaling
  • G-protein-coupled receptor
  • Nuclear estrogen receptors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Mechanism of cardioprotection : What can we learn from females? / Murphy, Elizabeth; Lagranha, Claudia; Deschamps, Anne; Kohr, Mark; Nguyen, Tiffany; Wong, Renee; Sun, Junhui; Steenbergen, Charles Jr.

In: Pediatric Cardiology, Vol. 32, No. 3, 03.2011, p. 354-359.

Research output: Contribution to journalArticle

Murphy, E, Lagranha, C, Deschamps, A, Kohr, M, Nguyen, T, Wong, R, Sun, J & Steenbergen, CJ 2011, 'Mechanism of cardioprotection: What can we learn from females?', Pediatric Cardiology, vol. 32, no. 3, pp. 354-359. https://doi.org/10.1007/s00246-010-9877-4
Murphy, Elizabeth ; Lagranha, Claudia ; Deschamps, Anne ; Kohr, Mark ; Nguyen, Tiffany ; Wong, Renee ; Sun, Junhui ; Steenbergen, Charles Jr. / Mechanism of cardioprotection : What can we learn from females?. In: Pediatric Cardiology. 2011 ; Vol. 32, No. 3. pp. 354-359.
@article{971ee6c359db4c3aa931b9bc8f8f3e15,
title = "Mechanism of cardioprotection: What can we learn from females?",
abstract = "This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.",
keywords = "Cardioprotection, Estrogen signaling, G-protein-coupled receptor, Nuclear estrogen receptors",
author = "Elizabeth Murphy and Claudia Lagranha and Anne Deschamps and Mark Kohr and Tiffany Nguyen and Renee Wong and Junhui Sun and Steenbergen, {Charles Jr}",
year = "2011",
month = "3",
doi = "10.1007/s00246-010-9877-4",
language = "English (US)",
volume = "32",
pages = "354--359",
journal = "Pediatric Cardiology",
issn = "0172-0643",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Mechanism of cardioprotection

T2 - What can we learn from females?

AU - Murphy, Elizabeth

AU - Lagranha, Claudia

AU - Deschamps, Anne

AU - Kohr, Mark

AU - Nguyen, Tiffany

AU - Wong, Renee

AU - Sun, Junhui

AU - Steenbergen, Charles Jr

PY - 2011/3

Y1 - 2011/3

N2 - This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.

AB - This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.

KW - Cardioprotection

KW - Estrogen signaling

KW - G-protein-coupled receptor

KW - Nuclear estrogen receptors

UR - http://www.scopus.com/inward/record.url?scp=79953761440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953761440&partnerID=8YFLogxK

U2 - 10.1007/s00246-010-9877-4

DO - 10.1007/s00246-010-9877-4

M3 - Article

VL - 32

SP - 354

EP - 359

JO - Pediatric Cardiology

JF - Pediatric Cardiology

SN - 0172-0643

IS - 3

ER -