Mechanism of cardioprotection: What can we learn from females?

Elizabeth Murphy, Claudia Lagranha, Anne Deschamps, Mark Kohr, Tiffany Nguyen, Renee Wong, Junhui Sun, Charles Steenbergen

Research output: Contribution to journalArticlepeer-review

Abstract

This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.

Original languageEnglish (US)
Pages (from-to)354-359
Number of pages6
JournalPediatric Cardiology
Volume32
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • Cardioprotection
  • Estrogen signaling
  • G-protein-coupled receptor
  • Nuclear estrogen receptors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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