Mechanism of anti-helper cell monoclonal antibody immunosuppression

W. R. Maley, L. W. Clow, J. F. Burdick

Research output: Contribution to journalArticle

Abstract

We investigated in vivo immunosuppression due to two antihelper cell antibodies by determining whether cell clearance was necessary for suppression of the allogeneic delayed-type hypersensitivity (DTH) response. B10.A mice treated with anti-Lyt 1 before sensitization with AKR lymphocytes demonstrated only a partial reduction (65%) in DTH responsiveness despite a 95% loss of the antigen (Table 1). When C57B1/6 mice were tested for DTH to DBA lymphocytes, treatment with anti-L3T4 produced a diminution in the DTH response that was dose dependent. This correlated with a progressive reduction in the L3T4+ cells in the spleen, ablation of the response occurring only with essentially maximal clearance of the L3T4+ cells.

Original languageEnglish (US)
Pages (from-to)263-264
Number of pages2
JournalTransplantation proceedings
Volume20
Issue number1 SUPPL. 1
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Surgery
  • Transplantation

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