Mechanics of the cell nucleus

Dong Hwee Kim, Jungwon Hah, Denis Wirtz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nucleus is a specialized organelle that serves as a control tower of all the cell behavior. While traditional biochemical features of nuclear signaling have been unveiled, many of the physical aspects of nuclear system are still under question. Innovative biophysical studies have recently identified mechano-regulation pathways that turn out to be critical in cell migration, particularly in cancer invasion and metastasis. Moreover, to take a deeper look onto the oncologic relevance of the nucleus, there has been a shift in cell systems. That is, our understanding of nucleus does not stand alone but it is understood by the relationship between cell and its microenvironment in the in vivo-relevant 3D space.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages41-55
Number of pages15
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1092
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Mechanotransduction
  • Nuclear envelope
  • Nuclear lamina
  • Nuclear mechanics
  • Nucleoskeleton

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Kim, D. H., Hah, J., & Wirtz, D. (2018). Mechanics of the cell nucleus. In Advances in Experimental Medicine and Biology (pp. 41-55). (Advances in Experimental Medicine and Biology; Vol. 1092). Springer New York LLC. https://doi.org/10.1007/978-3-319-95294-9_3