Mechanics of F-actin microenvironments probed by Brownian particles

James McGrath, John Hartwig, Scot Kuo

Research output: Contribution to journalConference articlepeer-review


By controlling the chemistry of particles embedded in F-actin gels, an attempt was made to demonstrate the important role of actin binding by probes in microrheological measurements. In both uncrosslinked and highly cross-linked networks, particles that bind F-actin report viscoelastic moduli comparable to those determined by macroscopic rheometry. By contrast, particles modified to prevent actin binding have weak microenvironments that are surprisingly insensitive to the introduction of filament cross-links.

Original languageEnglish (US)
Pages (from-to)S-91
JournalAnnals of biomedical engineering
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

ASJC Scopus subject areas

  • Biomedical Engineering


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