Mechanics of enveloped virus entry into host cells

Sean X. Sun, Denis Wirtz

Research output: Contribution to journalArticle

Abstract

Enveloped viruses such as HIV-1 enter their hosts by first establishing a contact region at the cell surface, which is stabilized by the formation of receptor-ligand complexes. We show that the favorable contact energy stemming from the formation of the receptor complexes in the interaction zone is sufficient to drive the engulfment of the virus by the cell. Using a continuum model, we show that the equilibrium engulfment depth and the force driving the engulfment are functions of the virus size and the complex formation energy. Resistance to engulfment is dominated by the elastic deformation of the cytoskeleton.

Original languageEnglish (US)
JournalBiophysical Journal
Volume90
Issue number1
DOIs
StatePublished - Jan 2006

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Virus Internalization
Mechanics
Viruses
Cytoskeleton
HIV-1
Ligands

ASJC Scopus subject areas

  • Biophysics

Cite this

Mechanics of enveloped virus entry into host cells. / Sun, Sean X.; Wirtz, Denis.

In: Biophysical Journal, Vol. 90, No. 1, 01.2006.

Research output: Contribution to journalArticle

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