Mechanics and regulation of cytokinesis

Douglas N. Robinson, James A. Spudich

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent advances are revealing quantitative aspects of cytokinesis. Further, genetic analyses and cell imaging are providing insights into the molecular dynamics of cleavage furrow ingression as well as further refining our knowledge of the zones of the mitotic spindle that regulate the contractile properties of the overlying cortex. Ultimately, however, cortical mechanics are the result of signals that emanate from the mitotic spindle. A genuine quantitative understanding of cytokinesis must include a thorough analysis of the mechanical properties of the cortex and how signals modify these properties to dictate a well-controlled, error-free cytokinesis.

Original languageEnglish (US)
Pages (from-to)182-188
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume16
Issue number2
DOIs
StatePublished - Apr 2004

Keywords

  • Arp2/3
  • F
  • FRET
  • Force
  • MHCK
  • MKLP
  • MLCK
  • PCH
  • PLK1
  • Polo-like kinase 1
  • R
  • actin-related protein 2/3
  • fluorescence resonance energy transfer
  • mitotic kinesin-like protein
  • myosin-II heavy chain kinase
  • myosin-II light chain kinase
  • pombe Cdc15 homology

ASJC Scopus subject areas

  • Cell Biology

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