Mechanical ventilation in acute lung injury and ARDS: Tidal volume reduction

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Traditional mechanical ventilation practices used generous tidal volumes in patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). This approach may have caused overdistention of aerated lung units, thus exacerbating lung injury in some patients. Several recent clinical trials of traditional versus lower tidal volume strategies in ALI/ARDS yielded disparate results. In the largest study, the lower tidal volume approach was associated with lower mortality and more ventilator-free days. This article reviews the rationale for tidal volume reduction in ALI/ARDS and the differences between the studies. Several different interpretations of the recent clinical trial results are addressed.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalCritical care clinics
Issue number1
StatePublished - 2002

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Mechanical ventilation in acute lung injury and ARDS: Tidal volume reduction'. Together they form a unique fingerprint.

Cite this