Mechanical signaling in reproductive tissues: Mechanisms and importance

Soledad Jorge, Sydney Chang, Joshua J. Barzilai, Phyllis Leppert, James H. Segars

Research output: Contribution to journalReview articlepeer-review


The organs of the female reproductive system are among the most dynamic tissues in the human body, undergoing repeated cycles of growth and involution from puberty through menopause. To achieve such impressive plasticity, reproductive tissues must respond not only to soluble signals (hormones, growth factors, and cytokines) but also to physical cues (mechanical forces and osmotic stress) as well. Here, we review the mechanisms underlying the process of mechanotransduction-how signals are conveyed from the extracellular matrix that surrounds the cells of reproductive tissues to the downstream molecules and signaling pathways that coordinate the cellular adaptive response to external forces. Our objective was to examine how mechanical forces contribute significantly to physiological functions and pathogenesis in reproductive tissues. We highlight how widespread diseases of the reproductive tract, from preterm labor to tumors of the uterus and breast, result from an impairment in mechanical signaling.

Original languageEnglish (US)
Pages (from-to)1093-1107
Number of pages15
JournalReproductive Sciences
Issue number9
StatePublished - Sep 1 2014
Externally publishedYes


  • ROCK/Rho kinase
  • cervical insufficiency
  • endometriosis
  • extracellular matrix
  • fibroids
  • mechanotransduction

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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