Mechanical Signaling and Extracellular Matrix in Uterine Fibroids

Saima Rafique, James H. Segars, Phyllis C. Leppert

Research output: Contribution to journalArticlepeer-review

Abstract

Fibroids (uterine leiomyomas) are the most common benign tumors of the female reproductive tract. Steroid hormones, growth factors, and cytokines have long been implicated in fibroid growth; however, research suggests that changes in the extracellular matrix and mechanical signaling play a critical role in fibroid growth and differentiation. Studies have shown that growth of fibroids is related to the change in the volume and composition of extracellular matrix with increased deposition of abnormal collagen, glycoproteins, laminins, fibronectins, and an increased osmotic stress. These changes generate mechanical stress which is converted to chemical signals in the cells through mechanotransduction and eventually affects gene expression and protein synthesis. Current studies also suggest that mechanical signaling in fibroid cells is abnormal as evidenced by decreased apoptosis of abnormal cells and deposition of a stiff extracellular matrix promoting fibrosis. Understanding and defining these mechanisms could help design new therapies for the treatment of fibroids.

Original languageEnglish (US)
Pages (from-to)487-493
Number of pages7
JournalSeminars in reproductive medicine
Volume35
Issue number6
DOIs
StatePublished - Nov 1 2017

Keywords

  • extracellular matrix
  • fibroids
  • mechanical signaling
  • mechanotransduction

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)

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