Measuring the retina optical properties using a structured illumination imaging system

A. Basiri, T. A. Nguyen, M. Ibrahim, Q. D. Nguyen, Jessica C. Ramella-Roman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Patients with diabetic retinopathy (DR) may experience a reduction in retinal oxygen saturation (SO2). Close monitoring with a fundus ophthalmoscope can help in the prediction of the progression of disease. In this paper we present a noninvasive instrument based on structured illumination aimed at measuring the retina optical properties including oxygen saturation. The instrument uses two wavelngths one in the NIR and one visible, a fast acquisition camera, and a splitter system that allows for contemporaneous collection of images at two different wavelengths. This scheme greatly reduces eye movement artifacts. Structured illumination was achieved in two different ways, firstly several binary illumination masks fabricated using laser micro-machining were used, a near-sinusoidal projection pattern is ultimately achieved at the image plane by appropriate positioning of the binary masks. Secondarily a sinusoidal pattern printed on a thin plastic sheet was positioned at image plane of a fundus ophthalmoscope. The system was calibrated using optical phantoms of known optical properties as well as an eye phantom that included a 150μm capillary vessel containing different concentrations of oxygenated and deoxygenated hemoglobin.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7885
DOIs
StatePublished - 2011
EventOphthalmic Technologies XXI - San Francisco, CA, United States
Duration: Jan 22 2011Jan 24 2011

Other

OtherOphthalmic Technologies XXI
CountryUnited States
CitySan Francisco, CA
Period1/22/111/24/11

Fingerprint

retina
Lighting
Imaging systems
Ophthalmoscopes
Retina
Optical properties
illumination
Masks
optical properties
masks
eye movements
Plastic sheets
Oxygen
saturation
Eye movements
Hemoglobin
hemoglobin
oxygen
Diabetic Retinopathy
Eye Movements

Keywords

  • modulated illumination
  • retina
  • Spectroscopy

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Basiri, A., Nguyen, T. A., Ibrahim, M., Nguyen, Q. D., & Ramella-Roman, J. C. (2011). Measuring the retina optical properties using a structured illumination imaging system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7885). [78851X] https://doi.org/10.1117/12.875146

Measuring the retina optical properties using a structured illumination imaging system. / Basiri, A.; Nguyen, T. A.; Ibrahim, M.; Nguyen, Q. D.; Ramella-Roman, Jessica C.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7885 2011. 78851X.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Basiri, A, Nguyen, TA, Ibrahim, M, Nguyen, QD & Ramella-Roman, JC 2011, Measuring the retina optical properties using a structured illumination imaging system. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7885, 78851X, Ophthalmic Technologies XXI, San Francisco, CA, United States, 1/22/11. https://doi.org/10.1117/12.875146
Basiri A, Nguyen TA, Ibrahim M, Nguyen QD, Ramella-Roman JC. Measuring the retina optical properties using a structured illumination imaging system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7885. 2011. 78851X https://doi.org/10.1117/12.875146
Basiri, A. ; Nguyen, T. A. ; Ibrahim, M. ; Nguyen, Q. D. ; Ramella-Roman, Jessica C. / Measuring the retina optical properties using a structured illumination imaging system. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7885 2011.
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