Measuring the longitudinal relaxation time of GABA in vivo at 3 Tesla

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Abstract

Purpose: To measure the in vivo longitudinal relaxation time T1 of GABA at 3 Tesla (T). Materials and Methods: J-difference edited single-voxel MR spectroscopy was used to isolate γ-aminobutyric acid (GABA) signals. An increased echo time (80 ms) acquisition was used, accommodating the longer, more selective editing pulses required for symmetric editing-based suppression of co-edited macromolecular signal. Acquiring edited GABA measurements at a range of relaxation times in 10 healthy participants, a saturation-recovery equation was used to model the integrated data. Results: The longitudinal relaxation time of GABA was measured as T1,GABA = 1.31 ± 0.16 s. Conclusion: The method described has been successfully applied to measure the T1 of GABA in vivo at 3T.

Original languageEnglish (US)
Pages (from-to)999-1003
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume37
Issue number4
DOIs
Publication statusPublished - Apr 2013

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Keywords

  • 3T
  • GABA
  • macromolecules
  • MEGA-PRESS
  • MRS
  • T1 relaxation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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