TY - JOUR
T1 - Measuring size and shape of the hippocampus in MR images using a deformable shape model
AU - Shen, Dinggang
AU - Moffat, Scott
AU - Resnick, Susan M.
AU - Davatzikos, Christos
PY - 2002/2
Y1 - 2002/2
N2 - A method for segmentation and quantification of the shape and size of the hippocampus is proposed, based on an automated image analysis algorithm. The algorithm uses a deformable shape model to locate the hippocampus in magnetic resonance images and to determine a geometric representation of its boundary. The deformable model combines three types of information. First, it employs information about the geometric properties of the hippocampal boundary, from a local and relatively finer scale to a more global and relatively coarser scale. Second, the model includes a statistical characterization of normal shape variation across individuals, serving as prior knowledge to the algorithm. Third, the algorithm utilizes a number of manually defined boundary points, which can help guide the model deformation to the appropriate boundaries, wherever these boundaries are weak or not clearly defined in MR images. Excellent agreement is demonstrated between the algorithm and manual segmentations by well-trained raters, with a correlation coefficient equal to 0.97 and algorithm/rater differences statistically equivalent to interrater differences for manual definitions.
AB - A method for segmentation and quantification of the shape and size of the hippocampus is proposed, based on an automated image analysis algorithm. The algorithm uses a deformable shape model to locate the hippocampus in magnetic resonance images and to determine a geometric representation of its boundary. The deformable model combines three types of information. First, it employs information about the geometric properties of the hippocampal boundary, from a local and relatively finer scale to a more global and relatively coarser scale. Second, the model includes a statistical characterization of normal shape variation across individuals, serving as prior knowledge to the algorithm. Third, the algorithm utilizes a number of manually defined boundary points, which can help guide the model deformation to the appropriate boundaries, wherever these boundaries are weak or not clearly defined in MR images. Excellent agreement is demonstrated between the algorithm and manual segmentations by well-trained raters, with a correlation coefficient equal to 0.97 and algorithm/rater differences statistically equivalent to interrater differences for manual definitions.
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U2 - 10.1006/nimg.2001.0987
DO - 10.1006/nimg.2001.0987
M3 - Article
C2 - 11798276
AN - SCOPUS:0036332127
SN - 1053-8119
VL - 15
SP - 422
EP - 434
JO - NeuroImage
JF - NeuroImage
IS - 2
ER -