Measuring random microscopic motion of water in tissues with mr imaging: A cat brain study

Denis Le Bihan, Chrit T.W. Moonen, Peter C.M. Van Zijl, James Pekar, Daryl Despres

Research output: Contribution to journalArticle

Abstract

Cat brain images sensitized to incoherent motion by additional gradient pulses were obtained on a 4.7 T magnetic resonance unit equipped with shielded gradient coils. The apparent diffusion coefficient of water in gray and white matter was accurately determined and imaged from the signal attenuation curve obtained as a function of gradient strength. Contrast in calculated diffusion images differed from typical T2-weighted contrast. Furthermore, in gray matter and in areas containing flowing CSF the attenuation curve was found to be biexponential. These results are interpreted in terms of a simple voxel model with microcirculation and diffusion contributions.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalJournal of computer assisted tomography
Volume15
Issue number1
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Keywords

  • Animal studies
  • Brain
  • Magnetic resonance imaging diffusion
  • Magnetic resonance imaging perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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