Measuring intermolecular binding forces with the atomic-force microscope: The magnetic jump method

Jan H. Hoh, Paul E. Hillner, Paul K. Hansma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A novel approach to measuring intermolecular forces with the atomic force microscope (AFM) that employs paramagnetic beads coated with one of the molecules to be studied is presented. The magnetic jump method for measuring intermolecular forces utilizes commercially available paramagnetic beads that are supplied in a variety of sizes with several well-defined and convenient coupling chemistries. Its principle is that the measured binding force will depend on the gradient of the external force applied to the bond. The magnetic interaction determines the external force applied gradient which can be several orders of magnitude smaller than the AFM cantilever force gradient.

Original languageEnglish (US)
Title of host publicationProceedings - Annual Meeting, Microscopy Society of America
EditorsG.W. Bailey, A.J. Garratt-Reed
Pages1054-1055
Number of pages2
StatePublished - 1994
Externally publishedYes
EventProceedings of the 52nd Annual Meeting of the Microscopy Society of America - New Orleans, LA, USA
Duration: Jul 31 1994Aug 5 1994

Other

OtherProceedings of the 52nd Annual Meeting of the Microscopy Society of America
CityNew Orleans, LA, USA
Period7/31/948/5/94

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Microscopes
Molecules

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hoh, J. H., Hillner, P. E., & Hansma, P. K. (1994). Measuring intermolecular binding forces with the atomic-force microscope: The magnetic jump method. In G. W. Bailey, & A. J. Garratt-Reed (Eds.), Proceedings - Annual Meeting, Microscopy Society of America (pp. 1054-1055)

Measuring intermolecular binding forces with the atomic-force microscope : The magnetic jump method. / Hoh, Jan H.; Hillner, Paul E.; Hansma, Paul K.

Proceedings - Annual Meeting, Microscopy Society of America. ed. / G.W. Bailey; A.J. Garratt-Reed. 1994. p. 1054-1055.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hoh, JH, Hillner, PE & Hansma, PK 1994, Measuring intermolecular binding forces with the atomic-force microscope: The magnetic jump method. in GW Bailey & AJ Garratt-Reed (eds), Proceedings - Annual Meeting, Microscopy Society of America. pp. 1054-1055, Proceedings of the 52nd Annual Meeting of the Microscopy Society of America, New Orleans, LA, USA, 7/31/94.
Hoh JH, Hillner PE, Hansma PK. Measuring intermolecular binding forces with the atomic-force microscope: The magnetic jump method. In Bailey GW, Garratt-Reed AJ, editors, Proceedings - Annual Meeting, Microscopy Society of America. 1994. p. 1054-1055
Hoh, Jan H. ; Hillner, Paul E. ; Hansma, Paul K. / Measuring intermolecular binding forces with the atomic-force microscope : The magnetic jump method. Proceedings - Annual Meeting, Microscopy Society of America. editor / G.W. Bailey ; A.J. Garratt-Reed. 1994. pp. 1054-1055
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