Measuring interconnection of the residual cortical functional islands in persistent vegetative state and minimal conscious state with EEG nonlinear analysis

Dong yu Wu, Gui Cai, Richard D. Zorowitz, Ying Yuan, Jie Wang, Wei qun Song

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of the study is to investigate the cortical response to painful and auditory stimuli for subjects in persistent vegetative state (PVS) and minimal conscious state (MCS), and measure the interconnection of the residual cortical functional islands with electroencephalographic (EEG) nonlinear dynamic analysis (NDA). Methods: Thirty PVS subjects, 20 MCS subjects and 30 subjects in normal conscious state (NCS) were involved in the study. EEG was recorded under three conditions: eyes closed, auditory stimuli and painful stimuli. EEG nonlinear index of cross-approximate entropy (C-ApEn) was calculated for all subjects. Results: Interconnection of local and distant cortical networks of patients in PVS was generally suppressed, and painful or auditory stimulation could hardly cause any activation of associative cortices. Instead, interconnection of local cortical networks of patients in MCS improved significantly. The only significant difference with the NCS existed in the unaffected distant cortical networks. Conclusions: Interconnection of local and distant cortical networks in MCS is superior to that of PVS. NDA could measure interconnection of the residual cortical functional islands with associative cortices in the unconscious patients. Significance: NDA can characterise the interconnection of cortical networks for the unconscious state and provide some information of unconsciousness at the awareness level.

Original languageEnglish (US)
Pages (from-to)1956-1966
Number of pages11
JournalClinical Neurophysiology
Volume122
Issue number10
DOIs
StatePublished - Oct 2011

Fingerprint

Persistent Vegetative State
Islands
Nonlinear Dynamics
Unconsciousness
Acoustic Stimulation
Entropy

Keywords

  • Electroencephalography
  • Nonlinear dynamics
  • Stroke
  • Traumatic brain injury
  • Unconsciousness

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Measuring interconnection of the residual cortical functional islands in persistent vegetative state and minimal conscious state with EEG nonlinear analysis. / Wu, Dong yu; Cai, Gui; Zorowitz, Richard D.; Yuan, Ying; Wang, Jie; Song, Wei qun.

In: Clinical Neurophysiology, Vol. 122, No. 10, 10.2011, p. 1956-1966.

Research output: Contribution to journalArticle

Wu, Dong yu ; Cai, Gui ; Zorowitz, Richard D. ; Yuan, Ying ; Wang, Jie ; Song, Wei qun. / Measuring interconnection of the residual cortical functional islands in persistent vegetative state and minimal conscious state with EEG nonlinear analysis. In: Clinical Neurophysiology. 2011 ; Vol. 122, No. 10. pp. 1956-1966.
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