Measuring indirect effects of rotavirus vaccine in low income countries

Aisleen Bennett, Naor Bar-Zeev, Nigel A. Cunliffe

Research output: Contribution to journalComment/debate

Abstract

Widespread introduction of rotavirus vaccines has led to major reductions in the burden of rotavirus gastroenteritis worldwide. Vaccine effectiveness is diminished, however, in low income countries, that harbour the greatest burden of rotavirus attributed morbidity and mortality. Indirect effects of rotavirus vaccine (herd immunity and herd protection) could increase population level impact and improve vaccine cost effectiveness in such settings. While rotavirus vaccine indirect effects have been demonstrated in high and middle income countries, there are very little data from low income countries where force of infection, population structures and vaccine schedules differ. Targeted efforts to evaluate indirect effects of rotavirus vaccine in low income countries are required to understand the total impact of rotavirus vaccine on the global burden of rotavirus disease.

Original languageEnglish (US)
Pages (from-to)4351-4353
Number of pages3
JournalVaccine
Volume34
Issue number37
DOIs
StatePublished - Aug 17 2016
Externally publishedYes

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Keywords

  • Gastroenteritis
  • Herd effects
  • Rotavirus
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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