Measuring coronary artery calcification: Is serum vitamin D relevant?

Rehan Malik, Ehimen C. Aneni, Lara Roberson, Oluseye Ogunmoroti, Shozab S. Ali, Sameer Shaharyar, Adnan Younus, Omar Jamal, Muhammad A. Aziz, Seth Martin, Michael Blaha, Theodore Feldman, Arthur S. Agatston, Emir Veledar, Khurram Nasir

Research output: Contribution to journalArticle

Abstract

Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.

Original languageEnglish (US)
Pages (from-to)734-738
Number of pages5
JournalAtherosclerosis
Volume237
Issue number2
DOIs
StatePublished - Dec 1 2014

Fingerprint

Vitamin D
Coronary Vessels
Calcium
Serum
Coronary Artery Disease
MEDLINE
Sample Size
Cross-Sectional Studies
Incidence

Keywords

  • Atherosclerosis
  • Coronary artery calcification
  • Serum vitamin D

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Malik, R., Aneni, E. C., Roberson, L., Ogunmoroti, O., Ali, S. S., Shaharyar, S., ... Nasir, K. (2014). Measuring coronary artery calcification: Is serum vitamin D relevant? Atherosclerosis, 237(2), 734-738. https://doi.org/10.1016/j.atherosclerosis.2014.10.087

Measuring coronary artery calcification : Is serum vitamin D relevant? / Malik, Rehan; Aneni, Ehimen C.; Roberson, Lara; Ogunmoroti, Oluseye; Ali, Shozab S.; Shaharyar, Sameer; Younus, Adnan; Jamal, Omar; Aziz, Muhammad A.; Martin, Seth; Blaha, Michael; Feldman, Theodore; Agatston, Arthur S.; Veledar, Emir; Nasir, Khurram.

In: Atherosclerosis, Vol. 237, No. 2, 01.12.2014, p. 734-738.

Research output: Contribution to journalArticle

Malik, R, Aneni, EC, Roberson, L, Ogunmoroti, O, Ali, SS, Shaharyar, S, Younus, A, Jamal, O, Aziz, MA, Martin, S, Blaha, M, Feldman, T, Agatston, AS, Veledar, E & Nasir, K 2014, 'Measuring coronary artery calcification: Is serum vitamin D relevant?', Atherosclerosis, vol. 237, no. 2, pp. 734-738. https://doi.org/10.1016/j.atherosclerosis.2014.10.087
Malik R, Aneni EC, Roberson L, Ogunmoroti O, Ali SS, Shaharyar S et al. Measuring coronary artery calcification: Is serum vitamin D relevant? Atherosclerosis. 2014 Dec 1;237(2):734-738. https://doi.org/10.1016/j.atherosclerosis.2014.10.087
Malik, Rehan ; Aneni, Ehimen C. ; Roberson, Lara ; Ogunmoroti, Oluseye ; Ali, Shozab S. ; Shaharyar, Sameer ; Younus, Adnan ; Jamal, Omar ; Aziz, Muhammad A. ; Martin, Seth ; Blaha, Michael ; Feldman, Theodore ; Agatston, Arthur S. ; Veledar, Emir ; Nasir, Khurram. / Measuring coronary artery calcification : Is serum vitamin D relevant?. In: Atherosclerosis. 2014 ; Vol. 237, No. 2. pp. 734-738.
@article{4ac682c9846c4afaa6eb2529eb8bdfa4,
title = "Measuring coronary artery calcification: Is serum vitamin D relevant?",
abstract = "Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.",
keywords = "Atherosclerosis, Coronary artery calcification, Serum vitamin D",
author = "Rehan Malik and Aneni, {Ehimen C.} and Lara Roberson and Oluseye Ogunmoroti and Ali, {Shozab S.} and Sameer Shaharyar and Adnan Younus and Omar Jamal and Aziz, {Muhammad A.} and Seth Martin and Michael Blaha and Theodore Feldman and Agatston, {Arthur S.} and Emir Veledar and Khurram Nasir",
year = "2014",
month = "12",
day = "1",
doi = "10.1016/j.atherosclerosis.2014.10.087",
language = "English (US)",
volume = "237",
pages = "734--738",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Measuring coronary artery calcification

T2 - Is serum vitamin D relevant?

AU - Malik, Rehan

AU - Aneni, Ehimen C.

AU - Roberson, Lara

AU - Ogunmoroti, Oluseye

AU - Ali, Shozab S.

AU - Shaharyar, Sameer

AU - Younus, Adnan

AU - Jamal, Omar

AU - Aziz, Muhammad A.

AU - Martin, Seth

AU - Blaha, Michael

AU - Feldman, Theodore

AU - Agatston, Arthur S.

AU - Veledar, Emir

AU - Nasir, Khurram

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.

AB - Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.

KW - Atherosclerosis

KW - Coronary artery calcification

KW - Serum vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84910600460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84910600460&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2014.10.087

DO - 10.1016/j.atherosclerosis.2014.10.087

M3 - Article

C2 - 25463113

AN - SCOPUS:84910600460

VL - 237

SP - 734

EP - 738

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -