Measuring arterial and tissue responses to functional challenges using arterial spin labeling

Yi Ching Lynn Ho, Esben Thade Petersen, Xavier Golay

Research output: Contribution to journalArticle

Abstract

The measurement of cerebral blood flow (CBF) in functional MRI studies that aim for non-invasive, quantitative and reliable measurements is a challenge. Here, we tested the feasibility of a recently developed, model-free CBF technique to study vascular dynamics upon functional challenges. Multiple inversion time-point signals were measured from arterial and tissue compartments, allowing for the calculation of CBF through a process of deconvolution. Using graded visual stimulation known to produce increasing hemodynamic responses, we recorded significant and graded ΔCBF and Δτm (microvascular arrival time change) that were highly comparable to those estimated by a standard 3-parameter fit based on the general kinetic model, though the absolute values had weaker agreement. Estimated arterial blood volumes (excluding substantial arteriolar contribution) did not show significant change with visual stimulation. Bolus arrival times in the microvascular compartment shortened more as compared to the arrival times from the arterial compartment during visual stimulation, suggesting larger involvement of the microvasculature in local neuronal response. While there are limitations, the model-free analysis method has the potential to offer useful vascular information in fMRI studies.

Original languageEnglish (US)
Pages (from-to)478-487
Number of pages10
JournalNeuroImage
Volume49
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

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Cerebrovascular Circulation
Photic Stimulation
Blood Vessels
Magnetic Resonance Imaging
Microvessels
Blood Volume
Hemodynamics

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Measuring arterial and tissue responses to functional challenges using arterial spin labeling. / Ho, Yi Ching Lynn; Petersen, Esben Thade; Golay, Xavier.

In: NeuroImage, Vol. 49, No. 1, 01.01.2010, p. 478-487.

Research output: Contribution to journalArticle

Ho, Yi Ching Lynn ; Petersen, Esben Thade ; Golay, Xavier. / Measuring arterial and tissue responses to functional challenges using arterial spin labeling. In: NeuroImage. 2010 ; Vol. 49, No. 1. pp. 478-487.
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