TY - GEN
T1 - Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography
AU - Chen, Siyu
AU - Yi, Ji
AU - Inayat, Sam
AU - Liu, Wenzhong
AU - Cang, Jianhua
AU - Zhang, Hao F.
N1 - Publisher Copyright:
© 2014 IEEE.
PY - 2014/11/2
Y1 - 2014/11/2
N2 - Understanding regulating mechanisms of cerebral blood flow (CBF) is important for clinical diagnosis and biomedical researches. We demonstrate here that phase sensitive Doppler optical coherence tomography is able to measure absolute CBF in mouse visual cortex in vivo when working in the visible-light spectral range. Both temporal and spatial profile of regional CBF variations can be resolved. We further assessed the accuracy of our method by in vitro experiments, which showed great consistency between the measured values and controlled ones. Finally, we enhanced the contrast of blood vessels to generate an angiogram showing great details of mouse cortical microvasculature.
AB - Understanding regulating mechanisms of cerebral blood flow (CBF) is important for clinical diagnosis and biomedical researches. We demonstrate here that phase sensitive Doppler optical coherence tomography is able to measure absolute CBF in mouse visual cortex in vivo when working in the visible-light spectral range. Both temporal and spatial profile of regional CBF variations can be resolved. We further assessed the accuracy of our method by in vitro experiments, which showed great consistency between the measured values and controlled ones. Finally, we enhanced the contrast of blood vessels to generate an angiogram showing great details of mouse cortical microvasculature.
UR - http://www.scopus.com/inward/record.url?scp=84929454655&partnerID=8YFLogxK
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U2 - 10.1109/EMBC.2014.6944471
DO - 10.1109/EMBC.2014.6944471
M3 - Conference contribution
C2 - 25570839
AN - SCOPUS:84929454655
T3 - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
SP - 3881
EP - 3884
BT - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Y2 - 26 August 2014 through 30 August 2014
ER -