Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography

Siyu Chen; Ji Yi; Sam Inayat; Wenzhong Liu; Jianhua Cang; Hao F. Zhang

doi:10.1109/EMBC.2014.6944471

Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography

Siyu Chen, Ji Yi, Sam Inayat, Wenzhong Liu, Jianhua Cang, Hao F. Zhang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Understanding regulating mechanisms of cerebral blood flow (CBF) is important for clinical diagnosis and biomedical researches. We demonstrate here that phase sensitive Doppler optical coherence tomography is able to measure absolute CBF in mouse visual cortex in vivo when working in the visible-light spectral range. Both temporal and spatial profile of regional CBF variations can be resolved. We further assessed the accuracy of our method by in vitro experiments, which showed great consistency between the measured values and controlled ones. Finally, we enhanced the contrast of blood vessels to generate an angiogram showing great details of mouse cortical microvasculature.

Original language	English (US)
Title of host publication	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	3881-3884
Number of pages	4
ISBN (Electronic)	9781424479290
DOIs	https://doi.org/10.1109/EMBC.2014.6944471
State	Published - Nov 2 2014
Externally published	Yes
Event	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States Duration: Aug 26 2014 → Aug 30 2014

Publication series

Name	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Other

Other	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Country/Territory	United States
City	Chicago
Period	8/26/14 → 8/30/14

ASJC Scopus subject areas

Health Informatics
Computer Science Applications
Biomedical Engineering
Medicine(all)

Access to Document

10.1109/EMBC.2014.6944471

Cite this

Chen, S., Yi, J., Inayat, S., Liu, W., Cang, J., & Zhang, H. F. (2014). Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 3881-3884). [6944471] (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6944471

Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography. / Chen, Siyu; Yi, Ji; Inayat, Sam et al.

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 3881-3884 6944471 (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chen, S, Yi, J, Inayat, S, Liu, W, Cang, J & Zhang, HF 2014, Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography. in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014., 6944471, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Institute of Electrical and Electronics Engineers Inc., pp. 3881-3884, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Chicago, United States, 8/26/14. https://doi.org/10.1109/EMBC.2014.6944471

Chen S, Yi J, Inayat S, Liu W, Cang J, Zhang HF. Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc. 2014. p. 3881-3884. 6944471. (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). https://doi.org/10.1109/EMBC.2014.6944471

Chen, Siyu ; Yi, Ji ; Inayat, Sam et al. / Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 3881-3884 (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

@inproceedings{6d6cf7059f5d480b8147c79e45dbce5c,

title = "Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography",

abstract = "Understanding regulating mechanisms of cerebral blood flow (CBF) is important for clinical diagnosis and biomedical researches. We demonstrate here that phase sensitive Doppler optical coherence tomography is able to measure absolute CBF in mouse visual cortex in vivo when working in the visible-light spectral range. Both temporal and spatial profile of regional CBF variations can be resolved. We further assessed the accuracy of our method by in vitro experiments, which showed great consistency between the measured values and controlled ones. Finally, we enhanced the contrast of blood vessels to generate an angiogram showing great details of mouse cortical microvasculature.",

author = "Siyu Chen and Ji Yi and Sam Inayat and Wenzhong Liu and Jianhua Cang and Zhang, {Hao F.}",

note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 ; Conference date: 26-08-2014 Through 30-08-2014",

year = "2014",

month = nov,

day = "2",

doi = "10.1109/EMBC.2014.6944471",

language = "English (US)",

series = "2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "3881--3884",

booktitle = "2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014",

}

TY - GEN

T1 - Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography

AU - Chen, Siyu

AU - Yi, Ji

AU - Inayat, Sam

AU - Liu, Wenzhong

AU - Cang, Jianhua

AU - Zhang, Hao F.

PY - 2014/11/2

Y1 - 2014/11/2

N2 - Understanding regulating mechanisms of cerebral blood flow (CBF) is important for clinical diagnosis and biomedical researches. We demonstrate here that phase sensitive Doppler optical coherence tomography is able to measure absolute CBF in mouse visual cortex in vivo when working in the visible-light spectral range. Both temporal and spatial profile of regional CBF variations can be resolved. We further assessed the accuracy of our method by in vitro experiments, which showed great consistency between the measured values and controlled ones. Finally, we enhanced the contrast of blood vessels to generate an angiogram showing great details of mouse cortical microvasculature.

AB - Understanding regulating mechanisms of cerebral blood flow (CBF) is important for clinical diagnosis and biomedical researches. We demonstrate here that phase sensitive Doppler optical coherence tomography is able to measure absolute CBF in mouse visual cortex in vivo when working in the visible-light spectral range. Both temporal and spatial profile of regional CBF variations can be resolved. We further assessed the accuracy of our method by in vitro experiments, which showed great consistency between the measured values and controlled ones. Finally, we enhanced the contrast of blood vessels to generate an angiogram showing great details of mouse cortical microvasculature.

UR - http://www.scopus.com/inward/record.url?scp=84929454655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929454655&partnerID=8YFLogxK

U2 - 10.1109/EMBC.2014.6944471

DO - 10.1109/EMBC.2014.6944471

M3 - Conference contribution

C2 - 25570839

AN - SCOPUS:84929454655

T3 - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

SP - 3881

EP - 3884

BT - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Y2 - 26 August 2014 through 30 August 2014

ER -

Measuring absolute microvascular blood flow in cortex using visible-light optical coherence tomography

Abstract

Publication series

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this