Measures of Body Size and Composition and Risk of Incident Atrial Fibrillation in Older People

Maria G. Karas, Laura M. Yee, Mary L. Biggs, Luc Djoussé, Kenneth J. Mukamal, H. Joachim, Susan J. Zieman, David S. Siscovick, John S. Gottdiener, Michael A. Rosenberg, Richard A. Kronmal, Susan R. Heckbert, Jorge R. Kizer

Research output: Contribution to journalArticle

Abstract

Various anthropometric measures, including height, have been associated with atrial fibrillation (AF). This raises questions about the appropriateness of using ratio measures such as body mass index (BMI), which contains height squared in its denominator, in the evaluation of AF risk. Among older adults, the optimal anthropometric approach to risk stratification of AF remains uncertain. Anthropometric and bioelectrical impedance measures were obtained from 4,276 participants (mean age = 72.4 years) free of cardiovascular disease in the Cardiovascular Health Study. During follow-up (1989-2008), 1,050 cases of AF occurred. BMI showed a U-shaped association, whereas height, weight, waist circumference, hip circumference, fat mass, and fat-free mass were linearly related to incident AF. The strongest adjusted association occurred for height (per each 1-standard-deviation increment, hazard ratio = 1.38, 95% confidence interval: 1.25, 1.51), which exceeded all other measures, including weight (hazard ratio = 1.21, 95% confidence interval: 1.13, 1.29). Combined assessment of log-transformed weight and height showed regression coefficients that departed from the 1 to -2 ratio inherent in BMI, indicating a loss of predictive information. Risk estimates for AF tended to be stronger for hip circumference than for waist circumference and for fat-free mass than for fat mass, which was explained largely by height. These findings highlight the prominent role of body size and the inadequacy of BMI as determinants of AF in older adults.

Original languageEnglish (US)
Pages (from-to)998-1007
Number of pages10
JournalAmerican Journal of Epidemiology
Volume183
Issue number11
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

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Keywords

  • aging
  • atrial fibrillation
  • body size
  • obesity

ASJC Scopus subject areas

  • Epidemiology

Cite this

Karas, M. G., Yee, L. M., Biggs, M. L., Djoussé, L., Mukamal, K. J., Joachim, H., Zieman, S. J., Siscovick, D. S., Gottdiener, J. S., Rosenberg, M. A., Kronmal, R. A., Heckbert, S. R., & Kizer, J. R. (2016). Measures of Body Size and Composition and Risk of Incident Atrial Fibrillation in Older People. American Journal of Epidemiology, 183(11), 998-1007. https://doi.org/10.1093/aje/kwv278