Measurement of the risk for substance use disorders: Phenotypic and genetic analysis of an index of common liability

Michael M. Vanyukov; Levent Kirisci; Lisa Moss; Ralph E. Tarter; Maureen D. Reynolds; Brion S. Maher; Galina P. Kirillova; Ty Ridenour; Duncan B. Clark

doi:10.1007/s10519-009-9269-9

Measurement of the risk for substance use disorders: Phenotypic and genetic analysis of an index of common liability

Michael M. Vanyukov, Levent Kirisci, Lisa Moss, Ralph E. Tarter, Maureen D. Reynolds, Brion S. Maher, Galina P. Kirillova, Ty Ridenour, Duncan B. Clark

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

The inability to quantify the risk for disorders, such as substance use disorders (SUD), hinders etiology research and development of targeted intervention. Based on the concept of common transmissible liability to SUD related to illicit drugs, a method enabling quantification of this latent trait has been developed, utilizing high-risk design and item response theory. This study examined properties of a SUD transmissible liability index (TLI) derived using this method. Sons of males with or without SUD were studied longitudinally from preadolescence to young adulthood. The properties of TLI, including its psychometric characteristics, longitudinal risk assessment and ethnic variation, were examined. A pilot twin study was conducted to analyze the composition of TLI's phenotypic variance. The data suggest that TLI has concurrent, incremental, predictive and discriminant validity, as well as ethnic differences. The data suggest a high heritability of the index in males. The results suggest applicability of the method for genetic and other etiology-related research, and for evaluation of individual risk.

Original language	English (US)
Pages (from-to)	233-244
Number of pages	12
Journal	Behavior Genetics
Volume	39
Issue number	3
DOIs	https://doi.org/10.1007/s10519-009-9269-9
State	Published - May 2009
Externally published	Yes

Keywords

Addiction
Ethnicity
IRT
Phenotype
Race
Transmissibility

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
Genetics(clinical)

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10.1007/s10519-009-9269-9

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title = "Measurement of the risk for substance use disorders: Phenotypic and genetic analysis of an index of common liability",

abstract = "The inability to quantify the risk for disorders, such as substance use disorders (SUD), hinders etiology research and development of targeted intervention. Based on the concept of common transmissible liability to SUD related to illicit drugs, a method enabling quantification of this latent trait has been developed, utilizing high-risk design and item response theory. This study examined properties of a SUD transmissible liability index (TLI) derived using this method. Sons of males with or without SUD were studied longitudinally from preadolescence to young adulthood. The properties of TLI, including its psychometric characteristics, longitudinal risk assessment and ethnic variation, were examined. A pilot twin study was conducted to analyze the composition of TLI's phenotypic variance. The data suggest that TLI has concurrent, incremental, predictive and discriminant validity, as well as ethnic differences. The data suggest a high heritability of the index in males. The results suggest applicability of the method for genetic and other etiology-related research, and for evaluation of individual risk.",

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author = "Vanyukov, {Michael M.} and Levent Kirisci and Lisa Moss and Tarter, {Ralph E.} and Reynolds, {Maureen D.} and Maher, {Brion S.} and Kirillova, {Galina P.} and Ty Ridenour and Clark, {Duncan B.}",

note = "Funding Information: Acknowledgments The authors are indebted to the staff of the Center for Education and Drug Abuse Research, University of Pittsburgh, for their effort and dedication. This study was supported by the National Institute on Drug Abuse grants P50DA005605, R01DA011922, R01DA019157, K02DA018701, K02DA017822, and the National Institute on Alcohol Abuse and Alcoholism grant K02AA00296",

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AU - Kirillova, Galina P.

AU - Ridenour, Ty

AU - Clark, Duncan B.

N1 - Funding Information: Acknowledgments The authors are indebted to the staff of the Center for Education and Drug Abuse Research, University of Pittsburgh, for their effort and dedication. This study was supported by the National Institute on Drug Abuse grants P50DA005605, R01DA011922, R01DA019157, K02DA018701, K02DA017822, and the National Institute on Alcohol Abuse and Alcoholism grant K02AA00296

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Measurement of the risk for substance use disorders: Phenotypic and genetic analysis of an index of common liability

Abstract

Keywords

ASJC Scopus subject areas

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