TY - JOUR
T1 - Measurement of myocardial mechanics in mice before and after infarction using multislice displacement-encoded MRI with 3D motion encoding
AU - Gilson, Wesley D.
AU - Yang, Zequan
AU - French, Brent A.
AU - Epstein, Frederick H.
PY - 2005/3
Y1 - 2005/3
N2 - Cardiac MRI is an accurate, noninvasive modality for assessing the structure and function of the murine heart. In addition to conventional imaging, MRI tissue tracking methods can quantify numerous aspects of myocardial mechanics, including intramyocardial displacement, strain, twist, and torsion: In the present study, we developed and applied a novel pulse sequence based on displacement-encoded imaging using stimulated echoes (DENSE) that achieves multislice coverage, high spatial resolution, and three-dimensional (3D) displacement encoding. With the use of this technique, myocardial mechanics of C57B1/6 mice were measured at baseline and 1 day after experimental myocardial infarction. At baseline, the mean systolic transmural circumferential strain was -0.14 ± 0.02 and the mean systolic radial strain was 0.30 ± 0.05. Changes in circumferential and radial strains from the subepicardium to the subendocardium were detected at baseline (P <0.05). One day after infarction, significantly reduced 3D displacements and strain were detected in infarcted and noninfarcted myocardium. Infarction also reduced normalized systolic torsion from its baseline value of 1.35 ± 0.27°/mm (R = 0.99) to 0.07 ± 0.54°/mm (R = 0.96, P <0.05). DENSE MRI can assess the 3D myocardial mechanics of the murine heart in
AB - Cardiac MRI is an accurate, noninvasive modality for assessing the structure and function of the murine heart. In addition to conventional imaging, MRI tissue tracking methods can quantify numerous aspects of myocardial mechanics, including intramyocardial displacement, strain, twist, and torsion: In the present study, we developed and applied a novel pulse sequence based on displacement-encoded imaging using stimulated echoes (DENSE) that achieves multislice coverage, high spatial resolution, and three-dimensional (3D) displacement encoding. With the use of this technique, myocardial mechanics of C57B1/6 mice were measured at baseline and 1 day after experimental myocardial infarction. At baseline, the mean systolic transmural circumferential strain was -0.14 ± 0.02 and the mean systolic radial strain was 0.30 ± 0.05. Changes in circumferential and radial strains from the subepicardium to the subendocardium were detected at baseline (P <0.05). One day after infarction, significantly reduced 3D displacements and strain were detected in infarcted and noninfarcted myocardium. Infarction also reduced normalized systolic torsion from its baseline value of 1.35 ± 0.27°/mm (R = 0.99) to 0.07 ± 0.54°/mm (R = 0.96, P <0.05). DENSE MRI can assess the 3D myocardial mechanics of the murine heart in
KW - Displacement-encoded imaging using stimulated echoes
KW - Left ventricular systolic function mouse
KW - Magnetic resonance imaging
KW - Myocardial contraction
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U2 - 10.1152/ajpheart.00632.2004
DO - 10.1152/ajpheart.00632.2004
M3 - Article
C2 - 15513963
AN - SCOPUS:13944256223
SN - 0363-6135
VL - 288
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 3 57-3
ER -