Measurement of exchangeable nickel in the rat

A. B. Chausmer

Research output: Contribution to journalArticle

Abstract

63Ni Cl2 was injected intravenously into rats which were exsanguinated at multiple time points following injection. Tissues were removed and analyzed for radionickel concentration. Tissue exchangeable pools were directly estimated and compartmental analysis performed by computer evaluation of the percent isotopic retention versus time. Kidney was found to have the largest rapidly exchangeable tissue pool with an approximate value of 10 ng/gm (wet wt.) during the first sixteen hours of study. Compartmental analysis was most compatible with two intracellular compartments in kidney, liver, lung and spleen. Bone had best fit with only one compartment. The rapid compartment in most tissues had half time of several hours, while the slower compartment had a half time of several days. The authors feel these data are consonant with the existance of a homeostatic mechanism operant for nickel.

Original languageEnglish (US)
Pages (from-to)323-336
Number of pages14
JournalNutrition Reports International
Volume14
Issue number3
StatePublished - 1976
Externally publishedYes

Fingerprint

Nickel
nickel
Rats
Tissue
rats
kidneys
Kidney
Liver
Bone
spleen
Spleen
lungs
bones
injection
Bone and Bones
Lung
liver
Injections
tissues

ASJC Scopus subject areas

  • Food Science
  • Biochemistry
  • Endocrinology
  • Medicine (miscellaneous)

Cite this

Measurement of exchangeable nickel in the rat. / Chausmer, A. B.

In: Nutrition Reports International, Vol. 14, No. 3, 1976, p. 323-336.

Research output: Contribution to journalArticle

Chausmer, AB 1976, 'Measurement of exchangeable nickel in the rat', Nutrition Reports International, vol. 14, no. 3, pp. 323-336.
Chausmer, A. B. / Measurement of exchangeable nickel in the rat. In: Nutrition Reports International. 1976 ; Vol. 14, No. 3. pp. 323-336.
@article{c64cd41966b94f9da3d53f2faa68172c,
title = "Measurement of exchangeable nickel in the rat",
abstract = "63Ni Cl2 was injected intravenously into rats which were exsanguinated at multiple time points following injection. Tissues were removed and analyzed for radionickel concentration. Tissue exchangeable pools were directly estimated and compartmental analysis performed by computer evaluation of the percent isotopic retention versus time. Kidney was found to have the largest rapidly exchangeable tissue pool with an approximate value of 10 ng/gm (wet wt.) during the first sixteen hours of study. Compartmental analysis was most compatible with two intracellular compartments in kidney, liver, lung and spleen. Bone had best fit with only one compartment. The rapid compartment in most tissues had half time of several hours, while the slower compartment had a half time of several days. The authors feel these data are consonant with the existance of a homeostatic mechanism operant for nickel.",
author = "Chausmer, {A. B.}",
year = "1976",
language = "English (US)",
volume = "14",
pages = "323--336",
journal = "Journal of Nutritional Biochemistry",
issn = "0955-2863",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Measurement of exchangeable nickel in the rat

AU - Chausmer, A. B.

PY - 1976

Y1 - 1976

N2 - 63Ni Cl2 was injected intravenously into rats which were exsanguinated at multiple time points following injection. Tissues were removed and analyzed for radionickel concentration. Tissue exchangeable pools were directly estimated and compartmental analysis performed by computer evaluation of the percent isotopic retention versus time. Kidney was found to have the largest rapidly exchangeable tissue pool with an approximate value of 10 ng/gm (wet wt.) during the first sixteen hours of study. Compartmental analysis was most compatible with two intracellular compartments in kidney, liver, lung and spleen. Bone had best fit with only one compartment. The rapid compartment in most tissues had half time of several hours, while the slower compartment had a half time of several days. The authors feel these data are consonant with the existance of a homeostatic mechanism operant for nickel.

AB - 63Ni Cl2 was injected intravenously into rats which were exsanguinated at multiple time points following injection. Tissues were removed and analyzed for radionickel concentration. Tissue exchangeable pools were directly estimated and compartmental analysis performed by computer evaluation of the percent isotopic retention versus time. Kidney was found to have the largest rapidly exchangeable tissue pool with an approximate value of 10 ng/gm (wet wt.) during the first sixteen hours of study. Compartmental analysis was most compatible with two intracellular compartments in kidney, liver, lung and spleen. Bone had best fit with only one compartment. The rapid compartment in most tissues had half time of several hours, while the slower compartment had a half time of several days. The authors feel these data are consonant with the existance of a homeostatic mechanism operant for nickel.

UR - http://www.scopus.com/inward/record.url?scp=0017111520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017111520&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0017111520

VL - 14

SP - 323

EP - 336

JO - Journal of Nutritional Biochemistry

JF - Journal of Nutritional Biochemistry

SN - 0955-2863

IS - 3

ER -