Measurement of cerebrospinal fluid retinol in subjects with HIV-1 infection

W. Royal, Richard David Semba, S. R. Park

Research output: Contribution to journalArticle

Abstract

In this study, retinol was measured in cerebrospinal fluid (CSF) and blood samples from 32 HIV-1-seropositive subjects and from 27 seronegative individuals with neurologic disease. In CSF, retinol was detected in 17 out of 32 (53.1%) HIV-1-seropositive and 20 out of 27 (74.1%) seronegative individuals (p = 0.16) and did not correlate with blood retinol levels. Serum vitamin A levels consistent with deficiency (3 (11 out of 24) than among those with 3 (one out of eight; p = 0.02), and CSF retinol concentration was greater for the group with (100 CD4+ lymphocytes/mm3 than those with + lymphocytes/mm3 (0.07 ± 0.018 μmol/l versus 0.007 ± 0.007 μmol/l; p = 0.01). This study suggests that CSF retinol levels are independent of measurements obtained in blood and, among HIV-1-seropositive subjects, may be lower for individuals with evidence of severe immunosuppression.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalImmunology and Infectious Diseases
Volume6
Issue number2
StatePublished - 1996

Fingerprint

Vitamin A
HIV Infections
Cerebrospinal Fluid
HIV-1
Lymphocytes
Nervous System Diseases
Immunosuppression
Serum

Keywords

  • AIDS
  • HIV-1 infection
  • Nervous system
  • Retinol

ASJC Scopus subject areas

  • Immunology

Cite this

Measurement of cerebrospinal fluid retinol in subjects with HIV-1 infection. / Royal, W.; Semba, Richard David; Park, S. R.

In: Immunology and Infectious Diseases, Vol. 6, No. 2, 1996, p. 99-103.

Research output: Contribution to journalArticle

@article{664e75fd100e4deabeed2d13648f3e56,
title = "Measurement of cerebrospinal fluid retinol in subjects with HIV-1 infection",
abstract = "In this study, retinol was measured in cerebrospinal fluid (CSF) and blood samples from 32 HIV-1-seropositive subjects and from 27 seronegative individuals with neurologic disease. In CSF, retinol was detected in 17 out of 32 (53.1{\%}) HIV-1-seropositive and 20 out of 27 (74.1{\%}) seronegative individuals (p = 0.16) and did not correlate with blood retinol levels. Serum vitamin A levels consistent with deficiency (3 (11 out of 24) than among those with 3 (one out of eight; p = 0.02), and CSF retinol concentration was greater for the group with (100 CD4+ lymphocytes/mm3 than those with + lymphocytes/mm3 (0.07 ± 0.018 μmol/l versus 0.007 ± 0.007 μmol/l; p = 0.01). This study suggests that CSF retinol levels are independent of measurements obtained in blood and, among HIV-1-seropositive subjects, may be lower for individuals with evidence of severe immunosuppression.",
keywords = "AIDS, HIV-1 infection, Nervous system, Retinol",
author = "W. Royal and Semba, {Richard David} and Park, {S. R.}",
year = "1996",
language = "English (US)",
volume = "6",
pages = "99--103",
journal = "Immunology and Infectious Diseases",
issn = "0959-4957",
publisher = "Rapid Communications of Oxford Ltd",
number = "2",

}

TY - JOUR

T1 - Measurement of cerebrospinal fluid retinol in subjects with HIV-1 infection

AU - Royal, W.

AU - Semba, Richard David

AU - Park, S. R.

PY - 1996

Y1 - 1996

N2 - In this study, retinol was measured in cerebrospinal fluid (CSF) and blood samples from 32 HIV-1-seropositive subjects and from 27 seronegative individuals with neurologic disease. In CSF, retinol was detected in 17 out of 32 (53.1%) HIV-1-seropositive and 20 out of 27 (74.1%) seronegative individuals (p = 0.16) and did not correlate with blood retinol levels. Serum vitamin A levels consistent with deficiency (3 (11 out of 24) than among those with 3 (one out of eight; p = 0.02), and CSF retinol concentration was greater for the group with (100 CD4+ lymphocytes/mm3 than those with + lymphocytes/mm3 (0.07 ± 0.018 μmol/l versus 0.007 ± 0.007 μmol/l; p = 0.01). This study suggests that CSF retinol levels are independent of measurements obtained in blood and, among HIV-1-seropositive subjects, may be lower for individuals with evidence of severe immunosuppression.

AB - In this study, retinol was measured in cerebrospinal fluid (CSF) and blood samples from 32 HIV-1-seropositive subjects and from 27 seronegative individuals with neurologic disease. In CSF, retinol was detected in 17 out of 32 (53.1%) HIV-1-seropositive and 20 out of 27 (74.1%) seronegative individuals (p = 0.16) and did not correlate with blood retinol levels. Serum vitamin A levels consistent with deficiency (3 (11 out of 24) than among those with 3 (one out of eight; p = 0.02), and CSF retinol concentration was greater for the group with (100 CD4+ lymphocytes/mm3 than those with + lymphocytes/mm3 (0.07 ± 0.018 μmol/l versus 0.007 ± 0.007 μmol/l; p = 0.01). This study suggests that CSF retinol levels are independent of measurements obtained in blood and, among HIV-1-seropositive subjects, may be lower for individuals with evidence of severe immunosuppression.

KW - AIDS

KW - HIV-1 infection

KW - Nervous system

KW - Retinol

UR - http://www.scopus.com/inward/record.url?scp=0030453221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030453221&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030453221

VL - 6

SP - 99

EP - 103

JO - Immunology and Infectious Diseases

JF - Immunology and Infectious Diseases

SN - 0959-4957

IS - 2

ER -