Measurement of aortic valve calcification using multislice computed tomography: Correlation with haemodynamic severity of aortic stenosis and clinical implication for patients with low ejection fraction

Caroline Cueff, Jean Michel Serfaty, Claire Cimadevilla, Jean Pierre Laissy, Dominique Himbert, Florence Tubach, Xavier Duval, Bernard Iung, Maurice Enriquez-Sarano, Alec Vahanian, David Messika-Zeitoun

Research output: Contribution to journalArticle

Abstract

Background Measurement of the degree of aortic valve calcification (AVC) using electron beam computed tomography (EBCT) is an accurate and complementary method to transthoracic echocardiography (TTE) for assessment of the severity of aortic stenosis (AS). Whether threshold values of AVC obtained with EBCT could be extrapolated to multislice computed tomography (MSCT) was unclear and AVC diagnostic value in patients with low ejection fraction (EF) has never been specifically evaluated. Methods Patients with mild to severe AS underwent prospectively within 1 week MSCT and TTE. Severe AS was defined as an aortic valve area (AVA) of less than 1 cm2. In 179 patients with EF greater than 40% (validation set), the relationship between AVC and AVA was evaluated. The best threshold of AVC for the diagnosis of severe AS was then evaluated in a second subset (testing set) of 49 patients with low EF (#40%). In this subgroup, AS severity was defined based on mean gradient, natural history or dobutamine stress echocardiography. Results Correlation between AVC and AVA was good (r=-0.63, p

Original languageEnglish (US)
Pages (from-to)721-726
Number of pages6
JournalHeart
Volume97
Issue number9
DOIs
StatePublished - May 2011
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Cueff, C., Serfaty, J. M., Cimadevilla, C., Laissy, J. P., Himbert, D., Tubach, F., Duval, X., Iung, B., Enriquez-Sarano, M., Vahanian, A., & Messika-Zeitoun, D. (2011). Measurement of aortic valve calcification using multislice computed tomography: Correlation with haemodynamic severity of aortic stenosis and clinical implication for patients with low ejection fraction. Heart, 97(9), 721-726. https://doi.org/10.1136/hrt.2010.198853