TY - JOUR
T1 - Measurement of antral follicle count in patients undergoing in vitro fertilization treatment
T2 - Results of a worldwide web-based survey
AU - Christianson, Mindy S.
AU - Shoham, Gon
AU - Tobler, Kyle J.
AU - Zhao, Yulian
AU - Cordeiro, Christina N.
AU - Leong, Milton
AU - Shoham, Zeev
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2015.
PY - 2015/10
Y1 - 2015/10
N2 - Purpose: The purpose of the present study was to identify trends in the therapeutic approaches used to measure antral follicle count (AFC) in patients undergoing in vitro fertilization (IVF) treatment worldwide. Methods: A retrospective evaluation utilizing the results of a web-based survey, IVF-Worldwide (www.IVF-Worldwide. com), was performed. Results: Responses from796 centers representing 593,200 cycles were evaluated. The majority of respondents (71.2%) considered antral follicle count as amandatory part of their practicewithmost (69.0 %) measuring AFC in the follicular phase. Most respondents (89.7 %) reported that they would modify the IVF stimulation protocol based on the AFC. There was considerable variation regarding a limit for the number of antral follicles required to initiate an IVF cycle with 46.1%designating three antral follicles as their limit, 39.9 % selecting either four or five follicles as their limit, and 14.0%reporting a higher cutoff criteria.With respect to antral follicle size, 61.5 % included follicles ranging between 2 and 10mm in the AFC. When asked to identify the best predictor of ovarian hyper-response during IVF cycles, AFC was selected most frequently (49.4 %), followed by anti-Mullerian hormone level (42.7 %). Age was selected as the best predictor of ongoing pregnancy rate in 81.7 % of respondents. Conclusions: While a large proportion of respondents utilized AFC as part of their daily practice and modified IVF protocol based on the measurement, the majority did not consider AFC as the best predictor of ongoing pregnancy rate.
AB - Purpose: The purpose of the present study was to identify trends in the therapeutic approaches used to measure antral follicle count (AFC) in patients undergoing in vitro fertilization (IVF) treatment worldwide. Methods: A retrospective evaluation utilizing the results of a web-based survey, IVF-Worldwide (www.IVF-Worldwide. com), was performed. Results: Responses from796 centers representing 593,200 cycles were evaluated. The majority of respondents (71.2%) considered antral follicle count as amandatory part of their practicewithmost (69.0 %) measuring AFC in the follicular phase. Most respondents (89.7 %) reported that they would modify the IVF stimulation protocol based on the AFC. There was considerable variation regarding a limit for the number of antral follicles required to initiate an IVF cycle with 46.1%designating three antral follicles as their limit, 39.9 % selecting either four or five follicles as their limit, and 14.0%reporting a higher cutoff criteria.With respect to antral follicle size, 61.5 % included follicles ranging between 2 and 10mm in the AFC. When asked to identify the best predictor of ovarian hyper-response during IVF cycles, AFC was selected most frequently (49.4 %), followed by anti-Mullerian hormone level (42.7 %). Age was selected as the best predictor of ongoing pregnancy rate in 81.7 % of respondents. Conclusions: While a large proportion of respondents utilized AFC as part of their daily practice and modified IVF protocol based on the measurement, the majority did not consider AFC as the best predictor of ongoing pregnancy rate.
KW - Antral follicle count
KW - In vitro fertilization
KW - Ovarian reserve
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U2 - 10.1007/s10815-015-0555-6
DO - 10.1007/s10815-015-0555-6
M3 - Article
C2 - 26341095
AN - SCOPUS:84983384136
SN - 1058-0468
VL - 32
SP - 1435
EP - 1440
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
IS - 10
ER -