Measurement of aflatoxin b1, its metabolites, and dna adducts by synchronous fluorescence spectrophotometry

Curtis C. Harris, Gerald LaVeck, Vincent L. Wilson, Dean Mann, John Groopman

Research output: Contribution to journalArticlepeer-review

Abstract

Sensitive and specific methods are needed for measuring human exposure to carcinogens. Synchronous fluorescence spectrophotometry can be used to measure fmol of afbitoxins their metabolites, and DNA adducts. Computer-assisted analysis of spectra of these agents obtained by synchronous fluorescence spectrophotometry can be displayed as contour maps which are highly specific for each agent. Individual agents in mixtures, e.g. aflatoxins B1 and M1, can be identified by fourth derivative spectral analysis. This physical method should complement immunological and other methods to measure aflatoxin B1, its metabolites, and nucleic acid adducts.

Original languageEnglish (US)
Pages (from-to)3249-3253
Number of pages5
JournalCancer Research
Volume46
Issue number7
StatePublished - Jul 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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