Measles virus-specific human T cell clones: Studies of alloreactivity and antigenic cross-reactivity

John R. Richert, Eve D. Robinson, Cynthia A. Reuben-Burnside, Armead H. Johnson, Henry F. McFarland, Dale E. McFarlin, Robert J. Hartzman

Research output: Contribution to journalArticle

Abstract

Cross-reactivity between altered self and foreign major histocompatibility complex (MHC) may be of etiologic importance in autoimmune disease. We have studied 29 measles virus-specific cloned and uncloned T cell lines from a patient with multiple sclerosis (MS) and from a normal subject. Two of the T cell clones derived from the normal subject reacted with foreign MHC determinants. No cross-reactivity between measles virus and either myelin basic protein (BP) or galactocerebroside (GC) was detected. T cell clones which are specific for nominal antigen and which also recognize alloantigen were detected with much smaller frequency than that reported in murine systems. Our data do not support a role for alloreactive measles-specific T cells, nor for cross-reactivity between measles virus and either BP or GC, in the pathogenesis of MS.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalJournal of Neuroimmunology
Volume19
Issue number1-2
DOIs
StatePublished - 1988
Externally publishedYes

Keywords

  • Alloreactivity
  • Galactocerebroside
  • Measles virus
  • Multiple sclerosis
  • Myelin basic protein
  • T cell clone

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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  • Cite this

    Richert, J. R., Robinson, E. D., Reuben-Burnside, C. A., Johnson, A. H., McFarland, H. F., McFarlin, D. E., & Hartzman, R. J. (1988). Measles virus-specific human T cell clones: Studies of alloreactivity and antigenic cross-reactivity. Journal of Neuroimmunology, 19(1-2), 59-68. https://doi.org/10.1016/0165-5728(88)90035-5