Abstract
Cross-reactivity between altered self and foreign major histocompatibility complex (MHC) may be of etiologic importance in autoimmune disease. We have studied 29 measles virus-specific cloned and uncloned T cell lines from a patient with multiple sclerosis (MS) and from a normal subject. Two of the T cell clones derived from the normal subject reacted with foreign MHC determinants. No cross-reactivity between measles virus and either myelin basic protein (BP) or galactocerebroside (GC) was detected. T cell clones which are specific for nominal antigen and which also recognize alloantigen were detected with much smaller frequency than that reported in murine systems. Our data do not support a role for alloreactive measles-specific T cells, nor for cross-reactivity between measles virus and either BP or GC, in the pathogenesis of MS.
Original language | English (US) |
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Pages (from-to) | 59-68 |
Number of pages | 10 |
Journal | Journal of Neuroimmunology |
Volume | 19 |
Issue number | 1-2 |
DOIs | |
State | Published - 1988 |
Externally published | Yes |
Keywords
- Alloreactivity
- Galactocerebroside
- Measles virus
- Multiple sclerosis
- Myelin basic protein
- T cell clone
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology