Measles virus polypeptide-specific antibody profile in multiple sclerosis

S. Dhib-Jalbut, K. Lewis, E. Bradburn, D. E. McFarlin, H. F. McFarland

Research output: Contribution to journalArticle

Abstract

Elevated antibody (Ab) titers to measles virus (MV) is a frequent finding in MS. Although MV-Abs are synthesized intrathecally, it is not known whether this is due to polyclonal activation of B cells recruited from the blood, recognition of MV antigens within the CNS, or cross-reactivity with myelin antigens. This study examined these possibilities using purified MV polypeptides. We examined Ab reactivity to each polypeptide in serum and CSF from 21 MS patients, 5 with subacute sclerosing panencephalitis (SSPE), and 11 patients with other neurologic diseases (OND), and serum from 5 patients with acute MV infection and 11 normal controls. The serum of all subjects tested contained reactivity with MV and the 5 polypeptides. Of 21 MS patients, 20 had CSF reactivity with MV compared with 3/11 ONDs and 5/5 SSPE patients. Intrathecal MVAb synthesis was present in 11/21 MS patients, 5/5 SSPE, and in none of the ONDs. Nine of 21 MS patients had intrathecal synthesis of Ab to 2 MV polypeptides. Serum and CSF reactivity in MS patients was skewed towards the F polypeptide. The results are consistent with the concept of polyclonal B cell activation within the CNS, but the heightened response to F could also reflect cross-reactivity with a relevant antigen in MS.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalNeurology
Volume40
Issue number3
StatePublished - 1990
Externally publishedYes

Fingerprint

Measles virus
Multiple Sclerosis
Peptides
Antibodies
Subacute Sclerosing Panencephalitis
Serum
Antigens
B-Lymphocytes
Virus
Virus Diseases
Myelin Sheath
Nervous System Diseases
Reactivity

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Dhib-Jalbut, S., Lewis, K., Bradburn, E., McFarlin, D. E., & McFarland, H. F. (1990). Measles virus polypeptide-specific antibody profile in multiple sclerosis. Neurology, 40(3), 430-435.

Measles virus polypeptide-specific antibody profile in multiple sclerosis. / Dhib-Jalbut, S.; Lewis, K.; Bradburn, E.; McFarlin, D. E.; McFarland, H. F.

In: Neurology, Vol. 40, No. 3, 1990, p. 430-435.

Research output: Contribution to journalArticle

Dhib-Jalbut, S, Lewis, K, Bradburn, E, McFarlin, DE & McFarland, HF 1990, 'Measles virus polypeptide-specific antibody profile in multiple sclerosis', Neurology, vol. 40, no. 3, pp. 430-435.
Dhib-Jalbut S, Lewis K, Bradburn E, McFarlin DE, McFarland HF. Measles virus polypeptide-specific antibody profile in multiple sclerosis. Neurology. 1990;40(3):430-435.
Dhib-Jalbut, S. ; Lewis, K. ; Bradburn, E. ; McFarlin, D. E. ; McFarland, H. F. / Measles virus polypeptide-specific antibody profile in multiple sclerosis. In: Neurology. 1990 ; Vol. 40, No. 3. pp. 430-435.
@article{2fe7e41ac6464926b839c48e528b92c1,
title = "Measles virus polypeptide-specific antibody profile in multiple sclerosis",
abstract = "Elevated antibody (Ab) titers to measles virus (MV) is a frequent finding in MS. Although MV-Abs are synthesized intrathecally, it is not known whether this is due to polyclonal activation of B cells recruited from the blood, recognition of MV antigens within the CNS, or cross-reactivity with myelin antigens. This study examined these possibilities using purified MV polypeptides. We examined Ab reactivity to each polypeptide in serum and CSF from 21 MS patients, 5 with subacute sclerosing panencephalitis (SSPE), and 11 patients with other neurologic diseases (OND), and serum from 5 patients with acute MV infection and 11 normal controls. The serum of all subjects tested contained reactivity with MV and the 5 polypeptides. Of 21 MS patients, 20 had CSF reactivity with MV compared with 3/11 ONDs and 5/5 SSPE patients. Intrathecal MVAb synthesis was present in 11/21 MS patients, 5/5 SSPE, and in none of the ONDs. Nine of 21 MS patients had intrathecal synthesis of Ab to 2 MV polypeptides. Serum and CSF reactivity in MS patients was skewed towards the F polypeptide. The results are consistent with the concept of polyclonal B cell activation within the CNS, but the heightened response to F could also reflect cross-reactivity with a relevant antigen in MS.",
author = "S. Dhib-Jalbut and K. Lewis and E. Bradburn and McFarlin, {D. E.} and McFarland, {H. F.}",
year = "1990",
language = "English (US)",
volume = "40",
pages = "430--435",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Measles virus polypeptide-specific antibody profile in multiple sclerosis

AU - Dhib-Jalbut, S.

AU - Lewis, K.

AU - Bradburn, E.

AU - McFarlin, D. E.

AU - McFarland, H. F.

PY - 1990

Y1 - 1990

N2 - Elevated antibody (Ab) titers to measles virus (MV) is a frequent finding in MS. Although MV-Abs are synthesized intrathecally, it is not known whether this is due to polyclonal activation of B cells recruited from the blood, recognition of MV antigens within the CNS, or cross-reactivity with myelin antigens. This study examined these possibilities using purified MV polypeptides. We examined Ab reactivity to each polypeptide in serum and CSF from 21 MS patients, 5 with subacute sclerosing panencephalitis (SSPE), and 11 patients with other neurologic diseases (OND), and serum from 5 patients with acute MV infection and 11 normal controls. The serum of all subjects tested contained reactivity with MV and the 5 polypeptides. Of 21 MS patients, 20 had CSF reactivity with MV compared with 3/11 ONDs and 5/5 SSPE patients. Intrathecal MVAb synthesis was present in 11/21 MS patients, 5/5 SSPE, and in none of the ONDs. Nine of 21 MS patients had intrathecal synthesis of Ab to 2 MV polypeptides. Serum and CSF reactivity in MS patients was skewed towards the F polypeptide. The results are consistent with the concept of polyclonal B cell activation within the CNS, but the heightened response to F could also reflect cross-reactivity with a relevant antigen in MS.

AB - Elevated antibody (Ab) titers to measles virus (MV) is a frequent finding in MS. Although MV-Abs are synthesized intrathecally, it is not known whether this is due to polyclonal activation of B cells recruited from the blood, recognition of MV antigens within the CNS, or cross-reactivity with myelin antigens. This study examined these possibilities using purified MV polypeptides. We examined Ab reactivity to each polypeptide in serum and CSF from 21 MS patients, 5 with subacute sclerosing panencephalitis (SSPE), and 11 patients with other neurologic diseases (OND), and serum from 5 patients with acute MV infection and 11 normal controls. The serum of all subjects tested contained reactivity with MV and the 5 polypeptides. Of 21 MS patients, 20 had CSF reactivity with MV compared with 3/11 ONDs and 5/5 SSPE patients. Intrathecal MVAb synthesis was present in 11/21 MS patients, 5/5 SSPE, and in none of the ONDs. Nine of 21 MS patients had intrathecal synthesis of Ab to 2 MV polypeptides. Serum and CSF reactivity in MS patients was skewed towards the F polypeptide. The results are consistent with the concept of polyclonal B cell activation within the CNS, but the heightened response to F could also reflect cross-reactivity with a relevant antigen in MS.

UR - http://www.scopus.com/inward/record.url?scp=0025215429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025215429&partnerID=8YFLogxK

M3 - Article

C2 - 2314583

AN - SCOPUS:0025215429

VL - 40

SP - 430

EP - 435

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 3

ER -