Measles virus infection of rhesus macaques affects neutrophil expression of IL-12 and IL-10

Scott J. Hoffman, Fernando P. Polack, Debra A. Hauer, Diane Griffin

Research output: Contribution to journalArticle

Abstract

Cytokine production by phagocytic cells is an important component of the immune response to infection with a variety of pathogens. Neutrophils are phagocytic cells capable of expressing interleukin (IL)-12 and IL-10 in response to infection with parasites, fungi, and bacteria. These cytokines are postulated to play important roles in the immune response during measles. Neutrophils isolated from naive or measles virus (MV)-infected rhesus macaques expressed IL-12 and IL-10 following in vitro stimulation with lipopolysaccharide (LPS) and interferon-gamma (IFN-γ). Stimulated neutrophils secreted proportionally more of the biologically active IL-12 heterodimer p70 and more IL-10 than similarly stimulated peripheral blood mononuclear cells (PBMCs). During MV infection, the number of IL-12 and IL-10-producing neutrophils and monocytes initially decreased. Subsequently, IL-12 levels were restored, and IL-10 expression rose above baseline in both cell types. Increased IL-10 production by neutrophils and monocytes during MV infection may play a role in measles-induced immunosuppression.

Original languageEnglish (US)
Pages (from-to)369-379
Number of pages11
JournalViral Immunology
Volume16
Issue number3
StatePublished - 2003

Fingerprint

Measles virus
Virus Diseases
Interleukin-12
Macaca mulatta
Interleukin-10
Neutrophils
Measles
Phagocytes
Monocytes
Cytokines
Parasitic Diseases
Immunosuppression
Interferon-gamma
Lipopolysaccharides
Blood Cells
Fungi
Bacteria
Infection

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Measles virus infection of rhesus macaques affects neutrophil expression of IL-12 and IL-10. / Hoffman, Scott J.; Polack, Fernando P.; Hauer, Debra A.; Griffin, Diane.

In: Viral Immunology, Vol. 16, No. 3, 2003, p. 369-379.

Research output: Contribution to journalArticle

Hoffman, Scott J. ; Polack, Fernando P. ; Hauer, Debra A. ; Griffin, Diane. / Measles virus infection of rhesus macaques affects neutrophil expression of IL-12 and IL-10. In: Viral Immunology. 2003 ; Vol. 16, No. 3. pp. 369-379.
@article{6e69c43ae1544f61a93f050e89024f67,
title = "Measles virus infection of rhesus macaques affects neutrophil expression of IL-12 and IL-10",
abstract = "Cytokine production by phagocytic cells is an important component of the immune response to infection with a variety of pathogens. Neutrophils are phagocytic cells capable of expressing interleukin (IL)-12 and IL-10 in response to infection with parasites, fungi, and bacteria. These cytokines are postulated to play important roles in the immune response during measles. Neutrophils isolated from naive or measles virus (MV)-infected rhesus macaques expressed IL-12 and IL-10 following in vitro stimulation with lipopolysaccharide (LPS) and interferon-gamma (IFN-γ). Stimulated neutrophils secreted proportionally more of the biologically active IL-12 heterodimer p70 and more IL-10 than similarly stimulated peripheral blood mononuclear cells (PBMCs). During MV infection, the number of IL-12 and IL-10-producing neutrophils and monocytes initially decreased. Subsequently, IL-12 levels were restored, and IL-10 expression rose above baseline in both cell types. Increased IL-10 production by neutrophils and monocytes during MV infection may play a role in measles-induced immunosuppression.",
author = "Hoffman, {Scott J.} and Polack, {Fernando P.} and Hauer, {Debra A.} and Diane Griffin",
year = "2003",
language = "English (US)",
volume = "16",
pages = "369--379",
journal = "Viral Immunology",
issn = "0882-8245",
publisher = "Mary Ann Liebert Inc.",
number = "3",

}

TY - JOUR

T1 - Measles virus infection of rhesus macaques affects neutrophil expression of IL-12 and IL-10

AU - Hoffman, Scott J.

AU - Polack, Fernando P.

AU - Hauer, Debra A.

AU - Griffin, Diane

PY - 2003

Y1 - 2003

N2 - Cytokine production by phagocytic cells is an important component of the immune response to infection with a variety of pathogens. Neutrophils are phagocytic cells capable of expressing interleukin (IL)-12 and IL-10 in response to infection with parasites, fungi, and bacteria. These cytokines are postulated to play important roles in the immune response during measles. Neutrophils isolated from naive or measles virus (MV)-infected rhesus macaques expressed IL-12 and IL-10 following in vitro stimulation with lipopolysaccharide (LPS) and interferon-gamma (IFN-γ). Stimulated neutrophils secreted proportionally more of the biologically active IL-12 heterodimer p70 and more IL-10 than similarly stimulated peripheral blood mononuclear cells (PBMCs). During MV infection, the number of IL-12 and IL-10-producing neutrophils and monocytes initially decreased. Subsequently, IL-12 levels were restored, and IL-10 expression rose above baseline in both cell types. Increased IL-10 production by neutrophils and monocytes during MV infection may play a role in measles-induced immunosuppression.

AB - Cytokine production by phagocytic cells is an important component of the immune response to infection with a variety of pathogens. Neutrophils are phagocytic cells capable of expressing interleukin (IL)-12 and IL-10 in response to infection with parasites, fungi, and bacteria. These cytokines are postulated to play important roles in the immune response during measles. Neutrophils isolated from naive or measles virus (MV)-infected rhesus macaques expressed IL-12 and IL-10 following in vitro stimulation with lipopolysaccharide (LPS) and interferon-gamma (IFN-γ). Stimulated neutrophils secreted proportionally more of the biologically active IL-12 heterodimer p70 and more IL-10 than similarly stimulated peripheral blood mononuclear cells (PBMCs). During MV infection, the number of IL-12 and IL-10-producing neutrophils and monocytes initially decreased. Subsequently, IL-12 levels were restored, and IL-10 expression rose above baseline in both cell types. Increased IL-10 production by neutrophils and monocytes during MV infection may play a role in measles-induced immunosuppression.

UR - http://www.scopus.com/inward/record.url?scp=0141960076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141960076&partnerID=8YFLogxK

M3 - Article

C2 - 14583151

AN - SCOPUS:0141960076

VL - 16

SP - 369

EP - 379

JO - Viral Immunology

JF - Viral Immunology

SN - 0882-8245

IS - 3

ER -