Measles virus infection of B lymphocytes permits cellular activation but blocks progression through the cell cycle

M. B. McChesney, J. H. Kehrl, A. Valsamakis, A. S. Fauci, M. B.A. Oldstone

Research output: Contribution to journalArticlepeer-review

Abstract

Measles virus infection of unstimulated B lymphocytes suppresses both proliferation and differentiation into immunoglobulin-secreting cells. However, mitogenic stimulation of these infected cells results in cell volume enlargement, rapid RNA synthesis, and the expression of cell surface activation antigens 4F2, HLA-DS and transferrin receptor. The cellular genes c-myc and histone 2B are induced during early G1 and S phase of the cell cycle, respetively, and viral RNA synthesis can be detected during this interval. However, total RNA synthesis is decreased at 48 h after stimulation, and the histone 2B RNA steady-state level at 48 h is fivefold less than that in uninfected cells. This sequence of events defines an arrest in the G1 phase of the cell cycle in measles virus-infected B cells.

Original languageEnglish (US)
Pages (from-to)3441-3447
Number of pages7
JournalJournal of virology
Volume61
Issue number11
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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