Measles mortality in high and low burden districts of India: Estimates from a nationally representative study of over 12,000 child deaths

Shaun K. Morris, Shally Awasthi, Rajesh Kumar, Anita Shet, Ajay Khera, Fatemeh Nakhaee, Usha Ram, Jose R.M. Brandao, Prabhat Jha

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Direct estimates of measles mortality in India are unavailable. Our objective is, to use a nationally-representative study of mortality to estimate the number and distribution of, measles deaths in India with a focus on 264 high burden districts. Methods: We used physician coded verbal autopsy data from the Million Death Study which surveyed, over 12,000 deaths in children aged 1 month to under 15 years from 1.1 million nationally, representative households in 2001-2003. Results: We estimate there were 92,000 (99% CI 63,000-137,000) measles deaths in children 1-59, months of age in India in 2005, representing a mortality rate of 3.3 (99% CI 2.3-5.0) per 1000 live, births and about 6% of all 1-59 month deaths. In children under 15 years of age, there were 107,000, (99% CI 74,000-158,000) measles deaths. The measles mortality rate was nearly 70% greater in girls, than in boys, and 60% of the deaths were in three populous states Uttar Pradesh, Bihar, and Madhya, Pradesh. The 1-59 month measles mortality rate in high burden districts was 4.48 (99% CI 3.94-5.02) compared to 2.40 (99% CI 2.28-2.52) per 1000 live births in other districts. Conclusion: Measles killed over 100,000 children in India in 2005 and girls were at higher risk than boys. The majority of measles deaths occurred in a few states and high burden districts. The results of this study highlight the importance of focusing measles supplementary immunization activities in high burden districts.

Original languageEnglish (US)
Pages (from-to)4655-4661
Number of pages7
JournalVaccine
Volume31
Issue number41
DOIs
StatePublished - Sep 23 2013
Externally publishedYes

Keywords

  • Childhood
  • Immunization
  • India
  • Measles
  • Mortality
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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