Measles immunity in children vaccinated before one year of age

Ann Schluederberg, Steven H. Lamm, Philip J. Landrigan, F. L. Black Rancis

Research output: Contribution to journalArticlepeer-review

Abstract

Schluederberg, A. (Yale University School of Medicine, New Haven, Conn. 06510), S. H. Lamm, P. J. Landrigan, and F. L. Black. Measles immunity in children vaccinated before one year of age. Am J Epidemiol 97: 402-409.-The immune status of children vaccinated before 1 year of age was investigated during a measles epidemic in an industrial section of Connecticut. Of the 61 documented cases which occurred in former recipients of live vaccine, 46% were children vaccinated before age 1; children vaccinated before 1 year of age comprised one-third of the total vaccinated population under study. The disproportionately increased number of cases in children vaccinated before their first birthday was not statistically significant. Of children vaccinated before age 1, 80% had demonstrable measles antibody. The geometric mean antibody titer of those vaccinated in infancy was lower than that of children vaccinated after 1 year of age (p <0.01). Following revaccination, 20 of 21 sero-negative children who had been vaccinated before age 1 year showed an IgG response without IgM; both IgM and IgG appeared following primary vaccination in 7 previously unvaccinated children. A child with measles encephalitis who had previously received live vaccine at 10 months of age also showed a secondary antibody response. The study suggests that infancy is only a relative contraindication of live measles virus vaccination; it further suggests that capacity for anamnestic response is not necessarily protective against measles. immunity; immunoglobulin M; measles vaccine; vaccination.

Original languageEnglish (US)
Pages (from-to)402-409
Number of pages8
JournalAmerican Journal of Epidemiology
Volume97
Issue number6
DOIs
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology

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