Meaningful associations in the adolescent brain cognitive development study

Anthony Steven Dick; Daniel A. Lopez; Ashley L. Watts; Steven Heeringa; Chase Reuter; Hauke Bartsch; Chun Chieh Fan; David N. Kennedy; Clare Palmer; Andrew Marshall; Frank Haist; Samuel Hawes; Thomas E. Nichols; Deanna M. Barch; Terry L. Jernigan; Hugh Garavan; Steven Grant; Vani Pariyadath; Elizabeth Hoffman; Michael Neale; Elizabeth A. Stuart; Martin P. Paulus; Kenneth J. Sher; Wesley K. Thompson

doi:10.1016/j.neuroimage.2021.118262

Meaningful associations in the adolescent brain cognitive development study

Anthony Steven Dick, Daniel A. Lopez, Ashley L. Watts, Steven Heeringa, Chase Reuter, Hauke Bartsch, Chun Chieh Fan, David N. Kennedy, Clare Palmer, Andrew Marshall, Frank Haist, Samuel Hawes, Thomas E. Nichols, Deanna M. Barch, Terry L. Jernigan, Hugh Garavan, Steven Grant, Vani Pariyadath, Elizabeth Hoffman, Michael NealeElizabeth A. Stuart, Martin P. Paulus, Kenneth J. Sher, Wesley K. Thompson

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n = 11,880 children aged 9–10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.

Original language	English (US)
Article number	118262
Journal	NeuroImage
Volume	239
DOIs	https://doi.org/10.1016/j.neuroimage.2021.118262
State	Published - Oct 1 2021

Keywords

Adolescent brain cognitive development study
Covariate Adjustments
Effect Sizes
Genetics
Hypothesis testing
Population neuroscience
Reproducibility

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2021.118262

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Dick, A. S., Lopez, D. A., Watts, A. L., Heeringa, S., Reuter, C., Bartsch, H., Fan, C. C., Kennedy, D. N., Palmer, C., Marshall, A., Haist, F., Hawes, S., Nichols, T. E., Barch, D. M., Jernigan, T. L., Garavan, H., Grant, S., Pariyadath, V., Hoffman, E., ... Thompson, W. K. (2021). Meaningful associations in the adolescent brain cognitive development study. NeuroImage, 239, Article 118262. https://doi.org/10.1016/j.neuroimage.2021.118262

Dick, AS, Lopez, DA, Watts, AL, Heeringa, S, Reuter, C, Bartsch, H, Fan, CC, Kennedy, DN, Palmer, C, Marshall, A, Haist, F, Hawes, S, Nichols, TE, Barch, DM, Jernigan, TL, Garavan, H, Grant, S, Pariyadath, V, Hoffman, E, Neale, M, Stuart, EA, Paulus, MP, Sher, KJ & Thompson, WK 2021, 'Meaningful associations in the adolescent brain cognitive development study', NeuroImage, vol. 239, 118262. https://doi.org/10.1016/j.neuroimage.2021.118262

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abstract = "The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n = 11,880 children aged 9–10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.",

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AU - Jernigan, Terry L.

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AU - Pariyadath, Vani

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AU - Thompson, Wesley K.

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AB - The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n = 11,880 children aged 9–10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.

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Meaningful associations in the adolescent brain cognitive development study

Abstract

Keywords

ASJC Scopus subject areas

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