Meaning of serum free-thyroxin values in nonthyroidal illnesses: Seven methods compared

D. W. Chan; J. M. Waud; E. Taylor; J. Stem; H. Drew; M. Oropeza; M. S. Sucupira

doi:10.1093/clinchem/29.12.2091

Meaning of serum free-thyroxin values in nonthyroidal illnesses: Seven methods compared

D. W. Chan, J. M. Waud, E. Taylor, J. Stem, H. Drew, M. Oropeza, M. S. Sucupira

School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Serum free-thyroxin (FT₄) was determined in 40 patients with various nonthyroidal illnesses. We studied seven methods: (1) a free thyroxin index calculated from total T₄ and triiodothyronine resin uptake; (2) a free T₄ index determined by enzyme inhibitor assays (Abbott's 'Tetrazyme' and 'Thyrozyme'); (3) a free T₄ index calculated from total T₄ and thyroxin-binding globulin; (4) free T₄ by equilibrium dialysis; (5) Amersham's free T₄ RIA; (6) Clinical Assays' one-step free T₄ RIA; and (7) Clinical Assays' two-step free T₄ RIA. Approximately half of the free T₄ results were in the euthyroid range and the other half in the hypothyroid range by methods 1, 2, 5, and 6. Results for free T₄ methods 3 and 7 were similar to those by equilibrium dialysis (method 4), the percentages of patients with results in the euthyroid range being 68%, 65%, and 76%, respectively.

Original language	English (US)
Pages (from-to)	2091-2093
Number of pages	3
Journal	Clinical chemistry
Volume	29
Issue number	12
DOIs	https://doi.org/10.1093/clinchem/29.12.2091
State	Published - Jan 1 1983

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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title = "Meaning of serum free-thyroxin values in nonthyroidal illnesses: Seven methods compared",

abstract = "Serum free-thyroxin (FT4) was determined in 40 patients with various nonthyroidal illnesses. We studied seven methods: (1) a free thyroxin index calculated from total T4 and triiodothyronine resin uptake; (2) a free T4 index determined by enzyme inhibitor assays (Abbott's 'Tetrazyme' and 'Thyrozyme'); (3) a free T4 index calculated from total T4 and thyroxin-binding globulin; (4) free T4 by equilibrium dialysis; (5) Amersham's free T4 RIA; (6) Clinical Assays' one-step free T4 RIA; and (7) Clinical Assays' two-step free T4 RIA. Approximately half of the free T4 results were in the euthyroid range and the other half in the hypothyroid range by methods 1, 2, 5, and 6. Results for free T4 methods 3 and 7 were similar to those by equilibrium dialysis (method 4), the percentages of patients with results in the euthyroid range being 68%, 65%, and 76%, respectively.",

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AU - Stem, J.

AU - Drew, H.

AU - Oropeza, M.

AU - Sucupira, M. S.

PY - 1983/1/1

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N2 - Serum free-thyroxin (FT4) was determined in 40 patients with various nonthyroidal illnesses. We studied seven methods: (1) a free thyroxin index calculated from total T4 and triiodothyronine resin uptake; (2) a free T4 index determined by enzyme inhibitor assays (Abbott's 'Tetrazyme' and 'Thyrozyme'); (3) a free T4 index calculated from total T4 and thyroxin-binding globulin; (4) free T4 by equilibrium dialysis; (5) Amersham's free T4 RIA; (6) Clinical Assays' one-step free T4 RIA; and (7) Clinical Assays' two-step free T4 RIA. Approximately half of the free T4 results were in the euthyroid range and the other half in the hypothyroid range by methods 1, 2, 5, and 6. Results for free T4 methods 3 and 7 were similar to those by equilibrium dialysis (method 4), the percentages of patients with results in the euthyroid range being 68%, 65%, and 76%, respectively.

AB - Serum free-thyroxin (FT4) was determined in 40 patients with various nonthyroidal illnesses. We studied seven methods: (1) a free thyroxin index calculated from total T4 and triiodothyronine resin uptake; (2) a free T4 index determined by enzyme inhibitor assays (Abbott's 'Tetrazyme' and 'Thyrozyme'); (3) a free T4 index calculated from total T4 and thyroxin-binding globulin; (4) free T4 by equilibrium dialysis; (5) Amersham's free T4 RIA; (6) Clinical Assays' one-step free T4 RIA; and (7) Clinical Assays' two-step free T4 RIA. Approximately half of the free T4 results were in the euthyroid range and the other half in the hypothyroid range by methods 1, 2, 5, and 6. Results for free T4 methods 3 and 7 were similar to those by equilibrium dialysis (method 4), the percentages of patients with results in the euthyroid range being 68%, 65%, and 76%, respectively.

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Meaning of serum free-thyroxin values in nonthyroidal illnesses: Seven methods compared

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