@article{d1d42dff38224cbb8941834a83db5a07,
title = "Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya",
abstract = "Platelet counts are decreased in Plasmodium falciparum malaria, which is aetiologically linked with endemic Burkitt lymphoma (eBL). However, the pattern of platelet counts in eBL cases is unknown. We studied platelet counts in 582 eBL cases and 2 248 controls enrolled in a case-control study in Uganda, Tanzania and Kenya (2010–2016). Mean platelet counts in controls or eBL cases with or without malaria-infection in controls versus eBLcases were compared using Student{\textquoteright}s t-test. Odds ratios (ORs) and two-sided 95% confidence intervals (95% CIs) were estimated using multiple logistic regression, controlling for age, sex, haemoglobin and white blood cell counts. Platelets were decreased with malaria infection in the controls [263 vs. 339 × 109 platelets/l, P < 0·0001; adjusted OR (aOR) = 3·42, 95% CI: 2·79–4·18] and eBL cases (314 vs. 367 × 109 platelets/l, P-value = 0·002; aOR = 2·36, 95% CI: 1·49–3·73). Unexpectedly, platelets were elevated in eBL cases versus controls in overall analyses (mean: 353 vs. 307 × 109 platelets/l, P < 0·0001; aOR = 1·41; 95% CI: 1·12–1·77), and when restricted to malaria-positive (mean 314 vs. 263 × 109 platelets/l, P < 0·0001; OR = 2·26; 95% CI: 1·56–3·27) or malaria-negative (mean 367 vs. 339 × 109 platelets/l, P < 0·001; OR = 1·46; 95% CI: 1·17–1·83) subjects. Platelets were decreased with malaria infection in controls and eBL cases but elevated with eBL.",
keywords = "Burkitt lymphoma, Epstein–Barr virus, Plasmodium falciparum malaria, epidemiology, non-Hodgkin lymphoma, platelet counts",
author = "Sally Peprah and Ogwang, {Martin D.} and Patrick Kerchan and Reynolds, {Steven J.} and Tenge, {Constance N.} and Were, {Pamela A.} and Kuremu, {Robert T.} and Wekesa, {Walter N.} and Nestory Masalu and Esther Kawira and Tobias Kinyera and Isaac Otim and Legason, {Ismail D.} and Hadijah Nabalende and Herry Dhudha and Mediatrix Mumia and Ayers, {Leona W.} and Biggar, {Robert J.} and Kishor Bhatia and Goedert, {James J.} and Mbulaiteye, {Sam M.}",
note = "Funding Information: We thank the study population and communities for their participation. We thank Ms. Janet Lawler-Heavner at Westat Inc, (Rockville, MD, USA) and Mr. Erisa Sunday at the African Field Epidemiology Network (Kampala, Uganda) for managing the study. We are grateful to the leadership of the collaborating countries and institutions for hosting local field offices and laboratories and supporting the fieldwork. We thank Ms. Laurie Buck, Dr. Carol Giffen, Mr. Greg Rydzak and Mr. Jeremy Lyman at Information Management Services Inc. (Calverton, MD, USA) for coordinating data, and preparing data analysis files. This work was supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI) (Contracts HHSN261201100063C and HHSN261201100007I) and, in part, by the Intramural Research Program, National Institute of Allergy and Infectious Diseases (SJR), National Institutes of Health, Department of Health and Human Services. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. Funding Information: This work was supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI) (Contracts HHSN261201100063C and HHSN261201100007I) and, in part, by the Intramural Research Program, National Institute of Allergy and Infectious Diseases (SJR), National Institutes of Health, Department of Health and Human Services. Publisher Copyright: {\textcopyright} 2020 British Society for Haematology and John Wiley & Sons Ltd",
year = "2020",
month = sep,
day = "1",
doi = "10.1111/bjh.16700",
language = "English (US)",
volume = "190",
pages = "772--782",
journal = "British journal of haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "5",
}