Meal-stimulated canine jejunal ionic absorption - Effect of direct jejunal meal delivery and premeal intravenous hydration

Gary J. Anthone, Zacharias V. Mavrophilipos, Michael J. Zinner, Bernadette H. Wang, Marlene S. Orandle, Charles J. Yeo

Research output: Contribution to journalArticle

Abstract

The ingestion of a meal stimulates water and ion absorption from the small intestine. The administration of nutrient substances directly to the small bowel can cause dumping symptoms, with intraluminal fluid accumulation and relative systemic hypovolemia. This study compared the effect of oral versus direct jejunal meal delivery on jejunal water and ion absorption, with and without premeal intravenous saline infusion. Jejunal absorption studies (N=40) were performed on dogs with 25 cm proximal jejunal Thiry-Vella fistulas and feeding jejunostomies. Luminal perfusion with [14C]PEG was used to calculate fluxes of water and electrolytes. Five groups were randomly studied: (1) intravenous 0.9% saline alone, (2) oral meal alone, (3) intravenous 0.9% saline plus oral meal, (4) jejunal meal alone, and (5) intravenous 0.9% saline plus jejunal meal. Hydration status was assessed hourly by measurement of hematocrit. Water and electrolyte absorption was significantly stimulated by both oral and jejunal meal delivery (P

Original languageEnglish (US)
Pages (from-to)842-848
Number of pages7
JournalDigestive Diseases and Sciences
Volume37
Issue number6
DOIs
StatePublished - Jun 1992

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Meals
Canidae
Water
Electrolytes
Ions
Jejunostomy
Hypovolemia
Hematocrit
Intravenous Infusions
Small Intestine
Fistula
Perfusion
Eating
Dogs
Food

Keywords

  • intestinal transport
  • ion flux
  • water flux

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Meal-stimulated canine jejunal ionic absorption - Effect of direct jejunal meal delivery and premeal intravenous hydration. / Anthone, Gary J.; Mavrophilipos, Zacharias V.; Zinner, Michael J.; Wang, Bernadette H.; Orandle, Marlene S.; Yeo, Charles J.

In: Digestive Diseases and Sciences, Vol. 37, No. 6, 06.1992, p. 842-848.

Research output: Contribution to journalArticle

Anthone, Gary J. ; Mavrophilipos, Zacharias V. ; Zinner, Michael J. ; Wang, Bernadette H. ; Orandle, Marlene S. ; Yeo, Charles J. / Meal-stimulated canine jejunal ionic absorption - Effect of direct jejunal meal delivery and premeal intravenous hydration. In: Digestive Diseases and Sciences. 1992 ; Vol. 37, No. 6. pp. 842-848.
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