Meal-stimulated absorption of water and electrolytes in canine jejunum

C. J. Yeo, J. A. Bastidas, R. E. Schmieg, M. J. Zinner

Research output: Contribution to journalArticle

Abstract

After a meal, the absorption of water and electrolytes from the jejunal lumen increases. This meal-induced jejunal absorption occurs in jejunal segments out of normal gastrointestinal continuity. The experimental model used 25-cm proximal jejunal Thiry-Vella loops in awake dogs (n = 72 observations) to evaluate the mechanisms involved in meal-induced jejunal absorption, seeking to define the source or sources of the proabsorptive signal. Specifically, we evaluated the jejunal absorptive response to a standard meal, a standard meal plus cholinergic blockage using atropine, a sham-fed meal, a gavage-fed meal, and gastric distension with balloon and gavage water. Both the standard meal and the gavage-fed meal induced a prompt, sustained, and significant (P <0.0001) increase in the absorption of H2O, Na+, and Cl-. Atropine significantly reduced the magnitude of the postmeal absorptive response (P <0.05) compared with the standard meal alone. The sham-fed meal, gastric balloon distension, and gavage water did not alter jejunal absorption. Vagal nerve integrity after cervical esophageal manipulation was verified by gastric acid output and gastrin response to stimuli. These data support a role for cholinergic modulation of meal-stimulated jejunal absorption via a cephalic-phase-independent and gastric-distension-independent mechanism.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume259
Issue number3 22-3
StatePublished - 1990

Fingerprint

Jejunum
Electrolytes
Meals
Canidae
Water
Atropine
Cholinergic Agents
Stomach
Gastric Balloon
Spinal Manipulation
Gastric Acid
Gastrins
Theoretical Models
Head
Dogs

Keywords

  • Atropine
  • Cephalic phase
  • Gastric phase
  • Ion flux
  • Ionic transport

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Meal-stimulated absorption of water and electrolytes in canine jejunum. / Yeo, C. J.; Bastidas, J. A.; Schmieg, R. E.; Zinner, M. J.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 259, No. 3 22-3, 1990.

Research output: Contribution to journalArticle

Yeo, C. J. ; Bastidas, J. A. ; Schmieg, R. E. ; Zinner, M. J. / Meal-stimulated absorption of water and electrolytes in canine jejunum. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 1990 ; Vol. 259, No. 3 22-3.
@article{3ee8db836c4e4a348e9f268243647a37,
title = "Meal-stimulated absorption of water and electrolytes in canine jejunum",
abstract = "After a meal, the absorption of water and electrolytes from the jejunal lumen increases. This meal-induced jejunal absorption occurs in jejunal segments out of normal gastrointestinal continuity. The experimental model used 25-cm proximal jejunal Thiry-Vella loops in awake dogs (n = 72 observations) to evaluate the mechanisms involved in meal-induced jejunal absorption, seeking to define the source or sources of the proabsorptive signal. Specifically, we evaluated the jejunal absorptive response to a standard meal, a standard meal plus cholinergic blockage using atropine, a sham-fed meal, a gavage-fed meal, and gastric distension with balloon and gavage water. Both the standard meal and the gavage-fed meal induced a prompt, sustained, and significant (P <0.0001) increase in the absorption of H2O, Na+, and Cl-. Atropine significantly reduced the magnitude of the postmeal absorptive response (P <0.05) compared with the standard meal alone. The sham-fed meal, gastric balloon distension, and gavage water did not alter jejunal absorption. Vagal nerve integrity after cervical esophageal manipulation was verified by gastric acid output and gastrin response to stimuli. These data support a role for cholinergic modulation of meal-stimulated jejunal absorption via a cephalic-phase-independent and gastric-distension-independent mechanism.",
keywords = "Atropine, Cephalic phase, Gastric phase, Ion flux, Ionic transport",
author = "Yeo, {C. J.} and Bastidas, {J. A.} and Schmieg, {R. E.} and Zinner, {M. J.}",
year = "1990",
language = "English (US)",
volume = "259",
journal = "American Journal of Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "3 22-3",

}

TY - JOUR

T1 - Meal-stimulated absorption of water and electrolytes in canine jejunum

AU - Yeo, C. J.

AU - Bastidas, J. A.

AU - Schmieg, R. E.

AU - Zinner, M. J.

PY - 1990

Y1 - 1990

N2 - After a meal, the absorption of water and electrolytes from the jejunal lumen increases. This meal-induced jejunal absorption occurs in jejunal segments out of normal gastrointestinal continuity. The experimental model used 25-cm proximal jejunal Thiry-Vella loops in awake dogs (n = 72 observations) to evaluate the mechanisms involved in meal-induced jejunal absorption, seeking to define the source or sources of the proabsorptive signal. Specifically, we evaluated the jejunal absorptive response to a standard meal, a standard meal plus cholinergic blockage using atropine, a sham-fed meal, a gavage-fed meal, and gastric distension with balloon and gavage water. Both the standard meal and the gavage-fed meal induced a prompt, sustained, and significant (P <0.0001) increase in the absorption of H2O, Na+, and Cl-. Atropine significantly reduced the magnitude of the postmeal absorptive response (P <0.05) compared with the standard meal alone. The sham-fed meal, gastric balloon distension, and gavage water did not alter jejunal absorption. Vagal nerve integrity after cervical esophageal manipulation was verified by gastric acid output and gastrin response to stimuli. These data support a role for cholinergic modulation of meal-stimulated jejunal absorption via a cephalic-phase-independent and gastric-distension-independent mechanism.

AB - After a meal, the absorption of water and electrolytes from the jejunal lumen increases. This meal-induced jejunal absorption occurs in jejunal segments out of normal gastrointestinal continuity. The experimental model used 25-cm proximal jejunal Thiry-Vella loops in awake dogs (n = 72 observations) to evaluate the mechanisms involved in meal-induced jejunal absorption, seeking to define the source or sources of the proabsorptive signal. Specifically, we evaluated the jejunal absorptive response to a standard meal, a standard meal plus cholinergic blockage using atropine, a sham-fed meal, a gavage-fed meal, and gastric distension with balloon and gavage water. Both the standard meal and the gavage-fed meal induced a prompt, sustained, and significant (P <0.0001) increase in the absorption of H2O, Na+, and Cl-. Atropine significantly reduced the magnitude of the postmeal absorptive response (P <0.05) compared with the standard meal alone. The sham-fed meal, gastric balloon distension, and gavage water did not alter jejunal absorption. Vagal nerve integrity after cervical esophageal manipulation was verified by gastric acid output and gastrin response to stimuli. These data support a role for cholinergic modulation of meal-stimulated jejunal absorption via a cephalic-phase-independent and gastric-distension-independent mechanism.

KW - Atropine

KW - Cephalic phase

KW - Gastric phase

KW - Ion flux

KW - Ionic transport

UR - http://www.scopus.com/inward/record.url?scp=0024991306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024991306&partnerID=8YFLogxK

M3 - Article

C2 - 2399984

AN - SCOPUS:0024991306

VL - 259

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6135

IS - 3 22-3

ER -