TY - JOUR
T1 - Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial)
AU - Silva, Diana
AU - Moreira, Rita
AU - Sokhatska, Oksana
AU - Beltrão, Marília
AU - Montanha, Tiago
AU - Garcia-Larsen, Vanessa
AU - Villegas, Rodrigo
AU - Severo, Milton
AU - Pizarro, Andreia
AU - Pinto, Mariana
AU - Martins, Carla
AU - Duarte, Ana
AU - Delgado, Luís
AU - Rufo, João
AU - Paciência, Inês
AU - Teixeira, João Paulo
AU - Costa, Carla
AU - Moreira, Pedro
AU - Carvalho, Joana
AU - Moreira, André
N1 - Publisher Copyright:
© 2018 The Authors
PY - 2018/6
Y1 - 2018/6
N2 - Background: The effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise Mediterranean meal (MdM) compared with a fast-food type meal (FFM) on exercise-induced immunological changes and 2) the impact of an induced acute period of sedentary behavior on neuro-immune-endocrine status. Methods: /Design: This is a two steps clinical trial including: (a) randomized crossover clinical trial, comparing the effect a high-fat/low-nutrient dense meal, FFM, with an isoenergetic similar high-nutrient dense meal, MdM, in the immune response to an exercise challenge (EC) and (b) a pilot trial assessing the neuro-immune-endocrine change induced by acute decreasing by half the usual physical activity level. Results: A total of 46 participants (26 females), median aged 25 years were included. Of those 39-completed protocol, including overweight, physical active and inactive and participants with asthma. There were no differences in the EC between interventions. Dietary factors and physical activity were closely monitored during interventions and kept similar. During physical inactivity induction, 31% reached the target of 50% reduction in mean step number and 77% reached a 30% reduction. Conclusion: The use of a pre-exercise meal to modulate immune response and the understanding of the immunological impact of physical inactivity might help to establish future recommendations on how to practice exercise in a safer way and to recognize the potential impact of inactivity.
AB - Background: The effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise Mediterranean meal (MdM) compared with a fast-food type meal (FFM) on exercise-induced immunological changes and 2) the impact of an induced acute period of sedentary behavior on neuro-immune-endocrine status. Methods: /Design: This is a two steps clinical trial including: (a) randomized crossover clinical trial, comparing the effect a high-fat/low-nutrient dense meal, FFM, with an isoenergetic similar high-nutrient dense meal, MdM, in the immune response to an exercise challenge (EC) and (b) a pilot trial assessing the neuro-immune-endocrine change induced by acute decreasing by half the usual physical activity level. Results: A total of 46 participants (26 females), median aged 25 years were included. Of those 39-completed protocol, including overweight, physical active and inactive and participants with asthma. There were no differences in the EC between interventions. Dietary factors and physical activity were closely monitored during interventions and kept similar. During physical inactivity induction, 31% reached the target of 50% reduction in mean step number and 77% reached a 30% reduction. Conclusion: The use of a pre-exercise meal to modulate immune response and the understanding of the immunological impact of physical inactivity might help to establish future recommendations on how to practice exercise in a safer way and to recognize the potential impact of inactivity.
KW - Allostatic load
KW - Exercise challenge
KW - Meal
KW - Physical inactivity
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U2 - 10.1016/j.conctc.2018.05.010
DO - 10.1016/j.conctc.2018.05.010
M3 - Article
C2 - 30009276
AN - SCOPUS:85046860304
SN - 2451-8654
VL - 10
SP - 177
EP - 189
JO - Contemporary Clinical Trials Communications
JF - Contemporary Clinical Trials Communications
ER -