MDM2 SNP309 and SNP354 are not associated with lung cancer risk

Sharon R. Pine; Leah E. Mechanic; Elise D. Bowman; Judith A. Welsh; Stephen C. Chanock; Peter G. Shields; Curtis C. Harris

doi:10.1158/1055-9965.EPI-06-0217

MDM2 SNP309 and SNP354 are not associated with lung cancer risk

Sharon R. Pine, Leah E. Mechanic, Elise D. Bowman, Judith A. Welsh, Stephen C. Chanock, Peter G. Shields, Curtis C. Harris

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been found to be associated with tumor formation. Publication of this null report is important because an association between MDM2 SNP309 and lung cancer was previously reported in two independent studies. Our findings suggest that MDM2 SNP309 is not a strong factor in lung carcinogenesis. In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls.

Original language	English (US)
Pages (from-to)	1559-1561
Number of pages	3
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	15
Issue number	8
DOIs	https://doi.org/10.1158/1055-9965.EPI-06-0217
State	Published - Aug 2006
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Oncology

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title = "MDM2 SNP309 and SNP354 are not associated with lung cancer risk",

abstract = "A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been found to be associated with tumor formation. Publication of this null report is important because an association between MDM2 SNP309 and lung cancer was previously reported in two independent studies. Our findings suggest that MDM2 SNP309 is not a strong factor in lung carcinogenesis. In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls.",

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T1 - MDM2 SNP309 and SNP354 are not associated with lung cancer risk

AU - Pine, Sharon R.

AU - Mechanic, Leah E.

AU - Bowman, Elise D.

AU - Welsh, Judith A.

AU - Chanock, Stephen C.

AU - Shields, Peter G.

AU - Harris, Curtis C.

PY - 2006/8

Y1 - 2006/8

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AB - A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been found to be associated with tumor formation. Publication of this null report is important because an association between MDM2 SNP309 and lung cancer was previously reported in two independent studies. Our findings suggest that MDM2 SNP309 is not a strong factor in lung carcinogenesis. In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls.

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MDM2 SNP309 and SNP354 are not associated with lung cancer risk

Abstract

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