MDM2 SNP309 and SNP354 are not associated with lung cancer risk

Sharon R. Pine, Leah E. Mechanic, Elise D. Bowman, Judith A. Welsh, Stephen C. Chanock, Peter G. Shields, Curtis C. Harris

Research output: Contribution to journalArticle

Abstract

A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been found to be associated with tumor formation. Publication of this null report is important because an association between MDM2 SNP309 and lung cancer was previously reported in two independent studies. Our findings suggest that MDM2 SNP309 is not a strong factor in lung carcinogenesis. In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls.

Original languageEnglish (US)
Pages (from-to)1559-1561
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number8
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Population Control
African Americans
Single Nucleotide Polymorphism
Publications
Lung Neoplasms
Carcinogenesis
Nucleotides
Lung
Population
Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Pine, S. R., Mechanic, L. E., Bowman, E. D., Welsh, J. A., Chanock, S. C., Shields, P. G., & Harris, C. C. (2006). MDM2 SNP309 and SNP354 are not associated with lung cancer risk. Cancer Epidemiology Biomarkers and Prevention, 15(8), 1559-1561. https://doi.org/10.1158/1055-9965.EPI-06-0217

MDM2 SNP309 and SNP354 are not associated with lung cancer risk. / Pine, Sharon R.; Mechanic, Leah E.; Bowman, Elise D.; Welsh, Judith A.; Chanock, Stephen C.; Shields, Peter G.; Harris, Curtis C.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 15, No. 8, 08.2006, p. 1559-1561.

Research output: Contribution to journalArticle

Pine, SR, Mechanic, LE, Bowman, ED, Welsh, JA, Chanock, SC, Shields, PG & Harris, CC 2006, 'MDM2 SNP309 and SNP354 are not associated with lung cancer risk', Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 8, pp. 1559-1561. https://doi.org/10.1158/1055-9965.EPI-06-0217
Pine SR, Mechanic LE, Bowman ED, Welsh JA, Chanock SC, Shields PG et al. MDM2 SNP309 and SNP354 are not associated with lung cancer risk. Cancer Epidemiology Biomarkers and Prevention. 2006 Aug;15(8):1559-1561. https://doi.org/10.1158/1055-9965.EPI-06-0217
Pine, Sharon R. ; Mechanic, Leah E. ; Bowman, Elise D. ; Welsh, Judith A. ; Chanock, Stephen C. ; Shields, Peter G. ; Harris, Curtis C. / MDM2 SNP309 and SNP354 are not associated with lung cancer risk. In: Cancer Epidemiology Biomarkers and Prevention. 2006 ; Vol. 15, No. 8. pp. 1559-1561.
@article{2d2dff93ef324e60bd38af467b1e5ce9,
title = "MDM2 SNP309 and SNP354 are not associated with lung cancer risk",
abstract = "A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been found to be associated with tumor formation. Publication of this null report is important because an association between MDM2 SNP309 and lung cancer was previously reported in two independent studies. Our findings suggest that MDM2 SNP309 is not a strong factor in lung carcinogenesis. In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls.",
author = "Pine, {Sharon R.} and Mechanic, {Leah E.} and Bowman, {Elise D.} and Welsh, {Judith A.} and Chanock, {Stephen C.} and Shields, {Peter G.} and Harris, {Curtis C.}",
year = "2006",
month = "8",
doi = "10.1158/1055-9965.EPI-06-0217",
language = "English (US)",
volume = "15",
pages = "1559--1561",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "8",

}

TY - JOUR

T1 - MDM2 SNP309 and SNP354 are not associated with lung cancer risk

AU - Pine, Sharon R.

AU - Mechanic, Leah E.

AU - Bowman, Elise D.

AU - Welsh, Judith A.

AU - Chanock, Stephen C.

AU - Shields, Peter G.

AU - Harris, Curtis C.

PY - 2006/8

Y1 - 2006/8

N2 - A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been found to be associated with tumor formation. Publication of this null report is important because an association between MDM2 SNP309 and lung cancer was previously reported in two independent studies. Our findings suggest that MDM2 SNP309 is not a strong factor in lung carcinogenesis. In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls.

AB - A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been found to be associated with tumor formation. Publication of this null report is important because an association between MDM2 SNP309 and lung cancer was previously reported in two independent studies. Our findings suggest that MDM2 SNP309 is not a strong factor in lung carcinogenesis. In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls.

UR - http://www.scopus.com/inward/record.url?scp=33748038740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748038740&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-06-0217

DO - 10.1158/1055-9965.EPI-06-0217

M3 - Article

C2 - 16896050

AN - SCOPUS:33748038740

VL - 15

SP - 1559

EP - 1561

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 8

ER -