MDCT angiography for detection of pulmonary emboli: Comparison between equi-iodine doses of iomeprol 400 mgI/mL and iodixanol 320 mgI/mL

Herbert Langenberger, Klaus Friedrich, Christina Plank, Wolfgang Matzek, Florian Wolf, Maria Luigia Storto, Cornelia Schaefer-Prokop, Christian Herold

Research output: Contribution to journalArticle

Abstract

Objectives: To compare iomeprol 400 and iodixanol 320 in pulmonary artery MDCTA in subjects with suspected pulmonary embolism. Methods: Eighty randomized subjects received equi-iodine intravenous doses (48 g) of iomeprol 400 (n = 40) or iodixanol 320 (n = 40), via power injector at 4 mL/s. Four-row (35 subjects) and 64-row (45 subjects) scanners were used. Lumen attenuation was determined on-site and by two off-site blinded readers in the main, lobar, segmental and subsegmental pulmonary arteries. Statistical comparison between groups was performed for demographics and lumen attenuation. Results: There were no between-group differences (p > 0.05) in demographics. Pulmonary artery attenuation was significantly (p ≤ 0.03) higher with iomeprol 400 for all readers. Attenuation quality was excellent in more patients after iomeprol 400 than after iodixanol-320 (80% vs. 62.5%; 82.5% vs. 77.5%; off-site readers 1 and 2, respectively). No safety concerns were noted. Conclusion: The greater iodine delivery rate achievable with iomeprol 400 compared to iodixanol-320 at equi-iodine dose and injection rate permits consistently greater attenuation at all levels of the pulmonary arterial tree.

Original languageEnglish (US)
Pages (from-to)579-588
Number of pages10
JournalEuropean Journal of Radiology
Volume70
Issue number3
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Embolism
Iodine
Angiography
Lung
Pulmonary Artery
Demography
Pulmonary Embolism
iomeprol
iodixanol
Safety
Injections

Keywords

  • Computed tomography (CT), angiography
  • Computed tomography (CT), contrast enhancement
  • Contrast media, comparative studies
  • Embolism, pulmonary
  • Pulmonary arteries, CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

MDCT angiography for detection of pulmonary emboli : Comparison between equi-iodine doses of iomeprol 400 mgI/mL and iodixanol 320 mgI/mL. / Langenberger, Herbert; Friedrich, Klaus; Plank, Christina; Matzek, Wolfgang; Wolf, Florian; Storto, Maria Luigia; Schaefer-Prokop, Cornelia; Herold, Christian.

In: European Journal of Radiology, Vol. 70, No. 3, 06.2009, p. 579-588.

Research output: Contribution to journalArticle

Langenberger, H, Friedrich, K, Plank, C, Matzek, W, Wolf, F, Storto, ML, Schaefer-Prokop, C & Herold, C 2009, 'MDCT angiography for detection of pulmonary emboli: Comparison between equi-iodine doses of iomeprol 400 mgI/mL and iodixanol 320 mgI/mL', European Journal of Radiology, vol. 70, no. 3, pp. 579-588. https://doi.org/10.1016/j.ejrad.2008.01.058
Langenberger, Herbert ; Friedrich, Klaus ; Plank, Christina ; Matzek, Wolfgang ; Wolf, Florian ; Storto, Maria Luigia ; Schaefer-Prokop, Cornelia ; Herold, Christian. / MDCT angiography for detection of pulmonary emboli : Comparison between equi-iodine doses of iomeprol 400 mgI/mL and iodixanol 320 mgI/mL. In: European Journal of Radiology. 2009 ; Vol. 70, No. 3. pp. 579-588.
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abstract = "Objectives: To compare iomeprol 400 and iodixanol 320 in pulmonary artery MDCTA in subjects with suspected pulmonary embolism. Methods: Eighty randomized subjects received equi-iodine intravenous doses (48 g) of iomeprol 400 (n = 40) or iodixanol 320 (n = 40), via power injector at 4 mL/s. Four-row (35 subjects) and 64-row (45 subjects) scanners were used. Lumen attenuation was determined on-site and by two off-site blinded readers in the main, lobar, segmental and subsegmental pulmonary arteries. Statistical comparison between groups was performed for demographics and lumen attenuation. Results: There were no between-group differences (p > 0.05) in demographics. Pulmonary artery attenuation was significantly (p ≤ 0.03) higher with iomeprol 400 for all readers. Attenuation quality was excellent in more patients after iomeprol 400 than after iodixanol-320 (80{\%} vs. 62.5{\%}; 82.5{\%} vs. 77.5{\%}; off-site readers 1 and 2, respectively). No safety concerns were noted. Conclusion: The greater iodine delivery rate achievable with iomeprol 400 compared to iodixanol-320 at equi-iodine dose and injection rate permits consistently greater attenuation at all levels of the pulmonary arterial tree.",
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AU - Friedrich, Klaus

AU - Plank, Christina

AU - Matzek, Wolfgang

AU - Wolf, Florian

AU - Storto, Maria Luigia

AU - Schaefer-Prokop, Cornelia

AU - Herold, Christian

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N2 - Objectives: To compare iomeprol 400 and iodixanol 320 in pulmonary artery MDCTA in subjects with suspected pulmonary embolism. Methods: Eighty randomized subjects received equi-iodine intravenous doses (48 g) of iomeprol 400 (n = 40) or iodixanol 320 (n = 40), via power injector at 4 mL/s. Four-row (35 subjects) and 64-row (45 subjects) scanners were used. Lumen attenuation was determined on-site and by two off-site blinded readers in the main, lobar, segmental and subsegmental pulmonary arteries. Statistical comparison between groups was performed for demographics and lumen attenuation. Results: There were no between-group differences (p > 0.05) in demographics. Pulmonary artery attenuation was significantly (p ≤ 0.03) higher with iomeprol 400 for all readers. Attenuation quality was excellent in more patients after iomeprol 400 than after iodixanol-320 (80% vs. 62.5%; 82.5% vs. 77.5%; off-site readers 1 and 2, respectively). No safety concerns were noted. Conclusion: The greater iodine delivery rate achievable with iomeprol 400 compared to iodixanol-320 at equi-iodine dose and injection rate permits consistently greater attenuation at all levels of the pulmonary arterial tree.

AB - Objectives: To compare iomeprol 400 and iodixanol 320 in pulmonary artery MDCTA in subjects with suspected pulmonary embolism. Methods: Eighty randomized subjects received equi-iodine intravenous doses (48 g) of iomeprol 400 (n = 40) or iodixanol 320 (n = 40), via power injector at 4 mL/s. Four-row (35 subjects) and 64-row (45 subjects) scanners were used. Lumen attenuation was determined on-site and by two off-site blinded readers in the main, lobar, segmental and subsegmental pulmonary arteries. Statistical comparison between groups was performed for demographics and lumen attenuation. Results: There were no between-group differences (p > 0.05) in demographics. Pulmonary artery attenuation was significantly (p ≤ 0.03) higher with iomeprol 400 for all readers. Attenuation quality was excellent in more patients after iomeprol 400 than after iodixanol-320 (80% vs. 62.5%; 82.5% vs. 77.5%; off-site readers 1 and 2, respectively). No safety concerns were noted. Conclusion: The greater iodine delivery rate achievable with iomeprol 400 compared to iodixanol-320 at equi-iodine dose and injection rate permits consistently greater attenuation at all levels of the pulmonary arterial tree.

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KW - Computed tomography (CT), contrast enhancement

KW - Contrast media, comparative studies

KW - Embolism, pulmonary

KW - Pulmonary arteries, CT

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