MDCT angiography for detection of pulmonary emboli: Comparison between equi-iodine doses of iomeprol 400 mgI/mL and iodixanol 320 mgI/mL

Herbert Langenberger, Klaus Friedrich, Christina Plank, Wolfgang Matzek, Florian Wolf, Maria Luigia Storto, Cornelia Schaefer-Prokop, Christian Herold

Research output: Contribution to journalArticle

Abstract

Objectives: To compare iomeprol 400 and iodixanol 320 in pulmonary artery MDCTA in subjects with suspected pulmonary embolism. Methods: Eighty randomized subjects received equi-iodine intravenous doses (48 g) of iomeprol 400 (n = 40) or iodixanol 320 (n = 40), via power injector at 4 mL/s. Four-row (35 subjects) and 64-row (45 subjects) scanners were used. Lumen attenuation was determined on-site and by two off-site blinded readers in the main, lobar, segmental and subsegmental pulmonary arteries. Statistical comparison between groups was performed for demographics and lumen attenuation. Results: There were no between-group differences (p > 0.05) in demographics. Pulmonary artery attenuation was significantly (p ≤ 0.03) higher with iomeprol 400 for all readers. Attenuation quality was excellent in more patients after iomeprol 400 than after iodixanol-320 (80% vs. 62.5%; 82.5% vs. 77.5%; off-site readers 1 and 2, respectively). No safety concerns were noted. Conclusion: The greater iodine delivery rate achievable with iomeprol 400 compared to iodixanol-320 at equi-iodine dose and injection rate permits consistently greater attenuation at all levels of the pulmonary arterial tree.

Original languageEnglish (US)
Pages (from-to)579-588
Number of pages10
JournalEuropean Journal of Radiology
Volume70
Issue number3
DOIs
StatePublished - Jun 1 2009

Keywords

  • Computed tomography (CT), angiography
  • Computed tomography (CT), contrast enhancement
  • Contrast media, comparative studies
  • Embolism, pulmonary
  • Pulmonary arteries, CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'MDCT angiography for detection of pulmonary emboli: Comparison between equi-iodine doses of iomeprol 400 mgI/mL and iodixanol 320 mgI/mL'. Together they form a unique fingerprint.

Cite this