Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection

Albert Vexler, Aiyi Liu, Ekaterina Eliseeva, Enrique F. Schisterman

Research output: Contribution to journalArticlepeer-review

Abstract

In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.

Original languageEnglish (US)
Pages (from-to)895-903
Number of pages9
JournalBiometrics
Volume64
Issue number3
DOIs
StatePublished - Sep 2008
Externally publishedYes

Keywords

  • Area under curve (AUC)
  • Censoring
  • Hypothesis testing
  • Limit of detection (LOD)
  • Maximum likelihood
  • Receiver operating characteristics (ROC)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Public Health, Environmental and Occupational Health
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics
  • Statistics and Probability

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