Abstract
In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.
Original language | English (US) |
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Pages (from-to) | 895-903 |
Number of pages | 9 |
Journal | Biometrics |
Volume | 64 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2008 |
Externally published | Yes |
Keywords
- Area under curve (AUC)
- Censoring
- Hypothesis testing
- Limit of detection (LOD)
- Maximum likelihood
- Receiver operating characteristics (ROC)
ASJC Scopus subject areas
- General Immunology and Microbiology
- Applied Mathematics
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences
- Statistics and Probability