Matrix‐assisted laser desorption of large biomolecules with a TEA‐CO2‐laser

A. Overberg, M. Karas, F. Hillenkamp, Robert J. Cotter

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


Matrix‐assisted desorption/ionization of large biomolecules with a TEA‐CO2 laser with a warelength of 10.6 μm is demonstrated. TEA‐CO2 LDI mass spectra are almost identical to those obtained with the Er‐YAG (2.94 μm) infra‐red (IR) laser and very similar to UV‐LDI spectra. Most of the matrices usable for Er‐YAG IR‐LDI have been tested at 10.6 μm with success, and the main features of IR‐LDI e.g., the tendency towards the formation of higher chargers is shown.

Original languageEnglish (US)
Pages (from-to)128-131
Number of pages4
JournalRapid Communications in Mass Spectrometry
Issue number3
StatePublished - 1991

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry


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