Matrix metalloproteinases, synaptic injury, and multiple sclerosis

Arek Szklarczyk; Katherine Conant

doi:10.3389/fpsyt.2010.00130

Matrix metalloproteinases, synaptic injury, and multiple sclerosis

Arek Szklarczyk, Katherine Conant

School of Medicine

Research output: Contribution to journal › Review article

Abstract

Multiple sclerosis (MS) is a disease of the central nervous system in which immune mediated damage to myelin is characteristic. For an overview of this condition and its pathophysiology, please refer to one of many excellent published reviews (Sorensen and Ransohoff, 1998; Weiner, 2009). To follow, is a discussion focused on the possibility that synaptic injury occurs in at least a subset of patients, and that matrix metalloproteinases (MMPs) play a role in such.

Original language	English (US)
Article number	Article 130
Journal	Frontiers in Psychiatry
Volume	1
Issue number	OCT
DOIs	https://doi.org/10.3389/fpsyt.2010.00130
State	Published - Dec 1 2010

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Keywords

Adhesion molecule
Cadherin
Icam
Matrix metalloproteinase
Mmp
Multiple sclerosis
Synapse

ASJC Scopus subject areas

Psychiatry and Mental health

Cite this

Szklarczyk, A., & Conant, K. (2010). Matrix metalloproteinases, synaptic injury, and multiple sclerosis. Frontiers in Psychiatry, 1(OCT), [Article 130]. https://doi.org/10.3389/fpsyt.2010.00130

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10.3389/fpsyt.2010.00130