Matrix metalloproteinases, synaptic injury, and multiple sclerosis

Arek Szklarczyk, Katherine Conant

Research output: Contribution to journalReview article

Abstract

Multiple sclerosis (MS) is a disease of the central nervous system in which immune mediated damage to myelin is characteristic. For an overview of this condition and its pathophysiology, please refer to one of many excellent published reviews (Sorensen and Ransohoff, 1998; Weiner, 2009). To follow, is a discussion focused on the possibility that synaptic injury occurs in at least a subset of patients, and that matrix metalloproteinases (MMPs) play a role in such.

Original languageEnglish (US)
Article numberArticle 130
JournalFrontiers in Psychiatry
Volume1
Issue numberOCT
DOIs
StatePublished - Dec 1 2010

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Keywords

  • Adhesion molecule
  • Cadherin
  • Icam
  • Matrix metalloproteinase
  • Mmp
  • Multiple sclerosis
  • Synapse

ASJC Scopus subject areas

  • Psychiatry and Mental health

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