Matrix metalloproteinases and the regulation of tissue remodelling

Andrea Page-McCaw, Andrew Ewald, Zena Werb

Research output: Contribution to journalArticle

Abstract

Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.

Original languageEnglish (US)
Pages (from-to)221-233
Number of pages13
JournalNature Reviews Molecular Cell Biology
Volume8
Issue number3
DOIs
StatePublished - Mar 2007
Externally publishedYes

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Matrix Metalloproteinases
Amphibians
Diptera
Peptide Hydrolases
Animal Models
Cell Culture Techniques
In Vitro Techniques

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Matrix metalloproteinases and the regulation of tissue remodelling. / Page-McCaw, Andrea; Ewald, Andrew; Werb, Zena.

In: Nature Reviews Molecular Cell Biology, Vol. 8, No. 3, 03.2007, p. 221-233.

Research output: Contribution to journalArticle

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