Matrix metalloproteinases and the regulation of tissue remodelling

Andrea Page-McCaw; Andrew J. Ewald; Zena Werb

doi:10.1038/nrm2125

Matrix metalloproteinases and the regulation of tissue remodelling

Andrea Page-McCaw, Andrew J. Ewald, Zena Werb

Research output: Contribution to journal › Review article › peer-review

1930 Scopus citations

Abstract

Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.

Original language	English (US)
Pages (from-to)	221-233
Number of pages	13
Journal	Nature Reviews Molecular Cell Biology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1038/nrm2125
State	Published - Mar 2007
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nrm2125

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title = "Matrix metalloproteinases and the regulation of tissue remodelling",

abstract = "Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.",

author = "Andrea Page-McCaw and Ewald, {Andrew J.} and Zena Werb",

note = "Funding Information: This study was supported by grants from the National Institutes of Health (NIH) to Z.W. and to A.P.-M and a March of Dimes Basil O{\textquoteright}Connor award to A.P.-M. A.J.E. was supported by an NIH National Research Service Award Institutional Fellowship and by the California Breast Cancer Research Program. We apologize to the many scientists whose papers we were unable to cite owing to space constraints.",

year = "2007",

month = mar,

doi = "10.1038/nrm2125",

language = "English (US)",

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pages = "221--233",

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T1 - Matrix metalloproteinases and the regulation of tissue remodelling

AU - Page-McCaw, Andrea

AU - Ewald, Andrew J.

AU - Werb, Zena

N1 - Funding Information: This study was supported by grants from the National Institutes of Health (NIH) to Z.W. and to A.P.-M and a March of Dimes Basil O’Connor award to A.P.-M. A.J.E. was supported by an NIH National Research Service Award Institutional Fellowship and by the California Breast Cancer Research Program. We apologize to the many scientists whose papers we were unable to cite owing to space constraints.

PY - 2007/3

Y1 - 2007/3

N2 - Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.

AB - Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.

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JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

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Matrix metalloproteinases and the regulation of tissue remodelling

Abstract

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