Abstract
Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 221-233 |
| Number of pages | 13 |
| Journal | Nature Reviews Molecular Cell Biology |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2007 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
Cite this
Matrix metalloproteinases and the regulation of tissue remodelling. / Page-McCaw, Andrea; Ewald, Andrew; Werb, Zena.
In: Nature Reviews Molecular Cell Biology, Vol. 8, No. 3, 03.2007, p. 221-233.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Matrix metalloproteinases and the regulation of tissue remodelling
AU - Page-McCaw, Andrea
AU - Ewald, Andrew
AU - Werb, Zena
PY - 2007/3
Y1 - 2007/3
N2 - Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.
AB - Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.
UR - http://www.scopus.com/inward/record.url?scp=33847195428&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847195428&partnerID=8YFLogxK
U2 - 10.1038/nrm2125
DO - 10.1038/nrm2125
M3 - Article
C2 - 17318226
AN - SCOPUS:33847195428
VL - 8
SP - 221
EP - 233
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
SN - 1471-0072
IS - 3
ER -