Matrix-implanted laser desorption/ionization mass spectrometry

Alexey Novikov, Martine Caroff, Serge Della-Negra, Yvon Lebeyec, Michèle Pautrat, J. Albert Schultz, Agnès Tempez, Hay Yan J Wang, Shelley N. Jackson, Amina S. Woods

Research output: Contribution to journalArticle


The implantation of low-velocity massive gold clusters is shown to be a method of choice for homogeneous incorporation of a metallic matrix into the near-surface region of a solid biopolymer for subsequent laser desorption/ionization (LDI) MS analysis. Matrix implanted (MI)LDI spectra from cluster-implanted pure test peptide or tissue exhibit molecular ion peaks similar to those observed by matrix-assisted LDI. Moreover, the ion emission is very reproducible from any spot on the surface of these test samples. MILDI promises to be a powerful technique for mass spectrometric analysis of native biological samples as demonstrated by the first results on rat brain tissues.

Original languageEnglish (US)
Pages (from-to)7288-7293
Number of pages6
JournalAnalytical Chemistry
Issue number24
StatePublished - Dec 15 2004
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry

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  • Cite this

    Novikov, A., Caroff, M., Della-Negra, S., Lebeyec, Y., Pautrat, M., Schultz, J. A., Tempez, A., Wang, H. Y. J., Jackson, S. N., & Woods, A. S. (2004). Matrix-implanted laser desorption/ionization mass spectrometry. Analytical Chemistry, 76(24), 7288-7293.