TY - JOUR
T1 - Maternal Zinc Supplementation Reduces Diarrheal Morbidity in Peruvian Infants
AU - Iannotti, Lora L.
AU - Zavaleta, Nelly
AU - León, Zulema
AU - Huasquiche, Clara
AU - Shankar, Anuraj H.
AU - Caulfield, Laura E.
N1 - Funding Information:
Supported by DAN-5116-A-00-8-51-00 and HRN-A- 00-97-00015-00, cooperative agreements with USAID/OHA, and The Johns Hopkins University . L.L.I. wrote the first draft of the manuscript with support from the T32HD046405-01A National Institutes of Health (NIH) International Maternal and Child Health Training Grant (2006). The study sponsors played no role in designing the study; collecting, analyzing, or interpreting the data; writing the report; or deciding to publish. The authors declare no conflicts of interest.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2010/6
Y1 - 2010/6
N2 - Objective: To test whether zinc supplementation during pregnancy would reduce infant morbidity rates. Study design: A double-blind, randomized controlled trial of prenatal zinc supplementation was conducted from 1995 to 1997 in a periurban slum of Lima, Peru. Participants were randomly assigned to receive daily supplementation with zinc (15 mg zinc + 60 mg iron + 250 μg folic acid) or placebo (60 iron + 250 μg folic acid) from 10 to 24 weeks gestation until 1 month postpartum. Anthropometry was measured monthly from birth through age 12 months, and morbidity and dietary intake were measured weekly from 6 to 12 months (n = 421). Results: The average percentage of observation days with diarrhea among infants prenatally treated with zinc (5.8%) was reduced compared with infants in the control group (7.7%) (P = .01). Prenatal zinc supplementation reduced the likelihood of an infant experiencing diarrheal episodes of acute diarrhea lasting longer than 7 days (OR 0.66, 95% CI 0.43, 0.99, P = .04) and mucus in the stool (OR 0.65 95% CI 0.46, 0.92, P = .01) adjusting for infant age, breastfeeding, season, and hygiene and sanitation covariates. No treatment effects on respiratory illnesses, fever, or skin conditions were detected. Conclusions: Improving prenatal zinc nutrition protected against diarrheal morbidity in infant offspring through 12 months of age.
AB - Objective: To test whether zinc supplementation during pregnancy would reduce infant morbidity rates. Study design: A double-blind, randomized controlled trial of prenatal zinc supplementation was conducted from 1995 to 1997 in a periurban slum of Lima, Peru. Participants were randomly assigned to receive daily supplementation with zinc (15 mg zinc + 60 mg iron + 250 μg folic acid) or placebo (60 iron + 250 μg folic acid) from 10 to 24 weeks gestation until 1 month postpartum. Anthropometry was measured monthly from birth through age 12 months, and morbidity and dietary intake were measured weekly from 6 to 12 months (n = 421). Results: The average percentage of observation days with diarrhea among infants prenatally treated with zinc (5.8%) was reduced compared with infants in the control group (7.7%) (P = .01). Prenatal zinc supplementation reduced the likelihood of an infant experiencing diarrheal episodes of acute diarrhea lasting longer than 7 days (OR 0.66, 95% CI 0.43, 0.99, P = .04) and mucus in the stool (OR 0.65 95% CI 0.46, 0.92, P = .01) adjusting for infant age, breastfeeding, season, and hygiene and sanitation covariates. No treatment effects on respiratory illnesses, fever, or skin conditions were detected. Conclusions: Improving prenatal zinc nutrition protected against diarrheal morbidity in infant offspring through 12 months of age.
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U2 - 10.1016/j.jpeds.2009.12.023
DO - 10.1016/j.jpeds.2009.12.023
M3 - Article
C2 - 20227716
AN - SCOPUS:77952288281
SN - 0022-3476
VL - 156
SP - 960-964.e2
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 6
ER -