Maternal XX/X chromosome mosaicism in donor oocyte in vitro fertilization (IVF)

Paul R. Brezina, Mindy S. Christianson, Khanh Ha D. Nguyen, Andrew Siegel, Andrew T. Benner, William G. Kearns

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate if the degree of maternal X chromosome mosaicism is correlated to the pregnancy loss rate in donor oocyte IVF in women with a Turner syndrome mosaic (TS-Mosaic) diagnosis. Design: Prospective trial. Patients and methods: Women with X chromosome Turner syndrome mosaicism and infertility were enrolled in a clinical trial. The rate of mosaicism was determined through florescence in situ hybridization (FISH) of 500 maternal lymphocytes. Following a detailed medical, including cardiac, evaluation, donor oocyte in vitro fertilization (IFV) was performed and pregnancy and pregnancy loss rates were observed. Results: The rates of maternal X chromosome mosaicism noted in the cycles from women with miscarriages (3%, 4%, 4%, and 6%) were not statistically different from cycles in TS-Mosaic women with normal deliveries (3% and 11%). These data suggest that the rate of maternal X chromosome mosaicism does not affect pregnancy loss rates in TS-Mosaic women undergoing donor oocyte IVF.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalMiddle East Fertility Society Journal
Volume17
Issue number2
DOIs
StatePublished - Jun 2012

Keywords

  • Donor oocyte
  • IVF
  • Mosaic
  • Mosaicism
  • Pregnancy
  • Turner syndrome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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