Maternal vitamin D status and calcium intake interact to affect fetal skeletal growth in utero in pregnant adolescents

Bridget E. Young, Thomas J. McNanley, Elizabeth M. Cooper, Allison W. McIntyre, Frank R Witter, Z. Leah Harris, Kimberly O. O'Brien

Research output: Contribution to journalArticle

Abstract

Background: Maternal calcium intake and vitamin D status may affect fetal bone development. Objective: This study was designed to examine relations between maternal calcium intake, 25-hydroxyvitamin D [25(OH)D] status, and fetal bone growth across pregnancy. Design: This was a prospective longitudinal design. Maternal 25(OH)D, parathyroid hormone, and 1,25-dihydroxyvitamin D [1,25(OH)2D] were determined at midgestation (∼26 wk) and at delivery in 171 adolescents (≤18 y). Dietary recalls and fetal sonograms were performed up to 3 times across gestation, and fetal femur and humerus z scores were generated. Results: Fetal femur and humerus z scores and neonatal birth length were significantly greater (P <0.03) in adolescents consuming ≥1050 mg than in those consuming 50 nmol/L was significantly positively associated with fetal femur and humerus z scores (P <0.01). When maternal smoking, height, race, weight gain, and gestational age were controlled for, these relations remained significant. Interactions between calcium intake and 25(OH)D were evident. Calcium intake was associated with fetal femur z scores and birth length only when maternal 25(OH)D was ≤50 nmol/L (P <0.05). Similarly, maternal 25(OH)D was associated with fetal femur and humerus z scores only when maternal calcium intake was

Original languageEnglish (US)
Pages (from-to)1103-1112
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume95
Issue number5
DOIs
StatePublished - May 1 2012

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Fetal Development
Vitamin D
Mothers
Calcium
Femur
Humerus
Bone Development
Parturition
Pregnancy
Parathyroid Hormone
Gestational Age
Weight Gain
Smoking

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Maternal vitamin D status and calcium intake interact to affect fetal skeletal growth in utero in pregnant adolescents. / Young, Bridget E.; McNanley, Thomas J.; Cooper, Elizabeth M.; McIntyre, Allison W.; Witter, Frank R; Harris, Z. Leah; O'Brien, Kimberly O.

In: American Journal of Clinical Nutrition, Vol. 95, No. 5, 01.05.2012, p. 1103-1112.

Research output: Contribution to journalArticle

Young, Bridget E. ; McNanley, Thomas J. ; Cooper, Elizabeth M. ; McIntyre, Allison W. ; Witter, Frank R ; Harris, Z. Leah ; O'Brien, Kimberly O. / Maternal vitamin D status and calcium intake interact to affect fetal skeletal growth in utero in pregnant adolescents. In: American Journal of Clinical Nutrition. 2012 ; Vol. 95, No. 5. pp. 1103-1112.
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