Maternal transmission of human immunodeficiency virus-1

Ido Paz, Daniel S. Seidman, Shlomo Mashiach, David K. Stevenson

Research output: Contribution to journalArticle

Abstract

The dramatic increase in the number of women of childbearing age infected with human immunodeficiency virus (HIV) has led to the revelation of another terrible consequence of the human immunodeficiency virus (HIV) pandemic; maternal transmission of HIV to the fetus. Over 90 per cent of the children who are infected with HIV contract the virus from their mother. Viral transmission may occur in utero, during labor when the newborn is exposed to maternal blood and body fluids or postnatally, mainly via breast-feeding. However, the risk of infection for a baby whose mother is an HIV carrier is not yet clear. The determination of the HIV status of the newborn remains a major diagnostic problem as the routine test, which detects antibodies to HIV, is of limited value in evaluating newborns. A summary of all of the large prospective long-term follow-up studies reported to date, shows an overall transmission rate of 22.4 per cent, with a 95 per cent confidence interval of 20.5 to 24.0 per cent. However, it is difficult to refer to the wide range of reported transmission rates, from 9.1 to 55.0 per cent, as they are confounded by the differing distribution of risk factors. The risk of maternal to newborn transmission must, therefore, be determined according to the specific characteristics of each parturient population.

Original languageEnglish (US)
Pages (from-to)577-584
Number of pages8
JournalObstetrical and Gynecological Survey
Volume49
Issue number8
StatePublished - 1994
Externally publishedYes

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HIV-1
Mothers
HIV
Newborn Infant
Body Fluids
Pandemics
Contracts
Breast Feeding
Fetus
Parturition
Confidence Intervals
Viruses
Antibodies
Infection
Population

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Paz, I., Seidman, D. S., Mashiach, S., & Stevenson, D. K. (1994). Maternal transmission of human immunodeficiency virus-1. Obstetrical and Gynecological Survey, 49(8), 577-584.

Maternal transmission of human immunodeficiency virus-1. / Paz, Ido; Seidman, Daniel S.; Mashiach, Shlomo; Stevenson, David K.

In: Obstetrical and Gynecological Survey, Vol. 49, No. 8, 1994, p. 577-584.

Research output: Contribution to journalArticle

Paz, I, Seidman, DS, Mashiach, S & Stevenson, DK 1994, 'Maternal transmission of human immunodeficiency virus-1', Obstetrical and Gynecological Survey, vol. 49, no. 8, pp. 577-584.
Paz I, Seidman DS, Mashiach S, Stevenson DK. Maternal transmission of human immunodeficiency virus-1. Obstetrical and Gynecological Survey. 1994;49(8):577-584.
Paz, Ido ; Seidman, Daniel S. ; Mashiach, Shlomo ; Stevenson, David K. / Maternal transmission of human immunodeficiency virus-1. In: Obstetrical and Gynecological Survey. 1994 ; Vol. 49, No. 8. pp. 577-584.
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